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Increased QT variability in patients with anorexia nervosa--an indicator for increased cardiac mortality?
MedLine Citation:
PMID:  19816863     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: Increased mortality in anorexia nervosa is associated with autonomic dysfunction and prolongation of the QT interval. In this study, we examined the relative importance of repolarization abnormalities and vagal modulation of heart rate. In particular, we hypothesized that patients with anorexia nervosa show increased QT interval variability, particularly since this measure has been shown to correlate with serious cardiac arrhythmias.
METHOD: We assessed linear and nonlinear heart rate variability (HRV) parameters as well as measures of QT variability in 20 female patients with anorexia nervosa and 20 controls. In patients, parameters were correlated with serum electrolytes.
RESULTS: QT variability was significantly increased in the patient group and correlated negatively with serum potassium concentrations. HRV measures showed a shift of autonomic balance towards vagal predominance.
DISCUSSION: The increase in QT variability might at least in part account for the higher risk of cardiac arrhythmias in patients with anorexia nervosa. Once validated in a prospective study design, parameters of QT variability might serve as surrogate markers for arrhythmia risk stratification in anorexia nervosa. Supplementation with potassium might normalize QT variability abnormalities.
Authors:
Mandy Koschke; Michael K Boettger; Claudia Macholdt; Steffen Schulz; Vikram K Yeragani; Andreas Voss; Karl-Jürgen Bär
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of eating disorders     Volume:  43     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-50     Citation Subset:  IM    
Copyright Information:
© 2009 by Wiley Periodicals, Inc.
Affiliation:
Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany.
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