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Increased prevalence of metabolic syndrome associated with rheumatoid arthritis in patients without clinical cardiovascular disease.
MedLine Citation:
PMID:  20952464     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: to examine whether patients with rheumatoid arthritis (RA) with no overt cardiovascular disease (CVD) have a higher prevalence of metabolic syndrome (MetS) than subjects without RA or CVD. We also examined whether RA disease characteristics are associated with the presence of MetS in RA patients without CVD.
METHODS: subjects from a population-based cohort of patients who fulfilled 1987 American College of Rheumatology criteria for RA between January 1, 1980, and December 31, 2007, were compared to non-RA subjects from the same population. All subjects with any history of CVD were excluded. Waist circumference, body mass index (BMI), and blood pressure were measured during the study visit. Data on CVD, lipids, and glucose measures were ascertained from medical records. MetS was defined using NCEP/ATP III criteria. Differences between the 2 cohorts were examined using logistic regression models adjusted for age and sex.
RESULTS: the study included 232 RA subjects without CVD and 1241 non-RA subjects without CVD. RA patients were significantly more likely to have increased waist circumference and elevated blood pressure than non-RA subjects, even though BMI was similar in both groups. Significantly more RA patients were classified as having MetS. In RA patients, MetS was associated with Health Assessment Questionnaire Disability Index, large-joint swelling, and uric acid levels, but not with C-reactive protein or RA therapies.
CONCLUSION: among subjects with no history of CVD, patients with RA are more likely to have MetS than non-RA subjects. MetS in patients with RA was associated with some measures of disease activity.
Cynthia S Crowson; Elena Myasoedova; John M Davis; Eric L Matteson; Veronique L Roger; Terry M Therneau; Patrick Fitz-Gibbon; Richard J Rodeheffer; Sherine E Gabriel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  38     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-29     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Department of Health Scienes Research, Division of Rheumatology, Mayo Clinic College of Medicine, MN 55905, USA.
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MeSH Terms
Arthritis, Rheumatoid / complications*
Blood Pressure
Cardiovascular Diseases / etiology*
Cross-Sectional Studies
Metabolic Syndrome X / complications*,  etiology*
Middle Aged
Risk Factors
Waist Circumference
Grant Support
AR30582/AR/NIAMS NIH HHS; R01 AG034676/AG/NIA NIH HHS; R01 AG034676-45/AG/NIA NIH HHS; R01 AG034676-46/AG/NIA NIH HHS; R01 AR046849/AR/NIAMS NIH HHS; R01 AR046849-10/AR/NIAMS NIH HHS; R01 AR46849/AR/NIAMS NIH HHS; R01 HL055502-08/HL/NHLBI NIH HHS; R01 HL55502/HL/NHLBI NIH HHS

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