| Increased Prevalence of Cardiovascular Disease in Type 1 Diabetic Patients with Non-Alcoholic Fatty Liver Disease. | |
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MedLine Citation:
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PMID: 21795844 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased prevalence of cardiovascular disease (CVD) in both non-diabetic and type 2 diabetic individuals. We sought to examine whether NAFLD is associated with prevalent CVD in patients with type 1 diabetes. Subjects and Methods: We studied 343 (156 men; mean age ∼45 years) consecutive type 1 diabetic patients with and without NAFLD, which was diagnosed by ultrasonography. The presence of CVD was diagnosed by patient history, chart review, electrocardiogram and echo-Doppler scanning of carotid and lower limb arteries. Results: Compared with those without steatosis, patients with ultrasound-diagnosed NAFLD (n=182) had a remarkably greater age- and sex-adjusted prevalence of coronary (15.4 vs. 1.2%, p<0.0001), cerebrovascular (41.7 vs. 9.3%, p<0.0001) and peripheral (29.7 vs. 6.2%, p<0.0001) vascular disease. A multivariable logistic regression analysis revealed that NAFLD was associated with an ~8-fold higher odds of CVD (composite endpoint), independently of age, sex, body mass index, family history of CVD, smoking status, physical activity, alcohol consumption, diabetes duration, hemoglobin A1c, systolic blood pressure, plasma lipids, estimated glomerular filtration rate, albuminuria and use of anti-hypertensive, lipid-lowering and anti-platelet medications (adjusted odds ratio 7.6, 95% confidence intervals 3.6-24.0, p<0.001). Conclusions: Our results demonstrate that NAFLD is associated with an increased prevalence of asymptomatic/symptomatic CVD in patients with type 1 diabetes, independently of several established risk factors, including the components of metabolic syndrome. |
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Authors:
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G Targher; I Pichiri; G Zoppini; M Trombetta; E Bonora |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-27 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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