| Increased postprandial response of glucagon-like peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency. | |
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MedLine Citation:
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PMID: 20460948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Glucagon-like peptide-2 (GLP-2) is a nutrient-released gastrointestinal (GI) hormone that acts as an intestinal growth factor, and exogenous GLP-2 has been shown to increase superior mesenteric artery (SMA) blood flow. We aimed to investigate how assimilation of nutrients affects postprandial GLP-2 responses and to correlate these with postprandial SMA blood flow. METHODS: Responses of the GI hormone glucose-dependent insulinotropic polypeptide (GIP) and GLP-2 were measured following an 80-min liquid meal test in 8 patients (6 males) with chronic pancreatitis (CP) and pancreatic exocrine insufficiency (PEI) and 8 healthy control subjects (5 males). Postprandial GI hormone responses were correlated with change in SMA flow as assessed by the resistance index. RESULTS: Patients with CP and PEI exhibited the greatest postprandial GLP-2 responses (1,870 +/- 249 vs. 1,199 +/- 108 pM.80 min, p = 0.027). No difference was observed with regard to GIP. GLP-2, but not GIP, responses correlated significantly with postprandial SMA flow. CONCLUSION: These results suggest that delayed assimilation of nutrients in patients with CP and PEI increases the secretion of GLP-2 - possibly due to delivery of a larger nutrient load to the distal part of the small intestine, where GLP-2 secreting L-cells are abundant - and that this hypersecretion of GLP-2 is associated with a higher SMA flow. |
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Authors:
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Mads Hornum; Jan F Pedersen; Steen Larsen; Ole Olsen; Jens J Holst; Filip K Knop |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-12 |
Journal Detail:
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Title: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Volume: 10 ISSN: 1424-3911 ISO Abbreviation: Pancreatology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966936 Medline TA: Pancreatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 201-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Nephrology, Copenhagen University Hospital, Rigshospitalet, Denmark. mads.hornum@rh.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Exocrine Pancreatic Insufficiency
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blood* Female Gastric Inhibitory Polypeptide / blood Glucagon-Like Peptide 2 / blood* Humans Male Mesenteric Artery, Superior / physiology Pancreatitis, Chronic / blood* Postprandial Period Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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0/Glucagon-Like Peptide 2; 59392-49-3/Gastric Inhibitory Polypeptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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