| Increased plasma d-lactic acid associated with impaired memory in rats. | |
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MedLine Citation:
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PMID: 20888356 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: d-Lactic acidosis is associated with memory impairment in humans. Recent research indicates that d-lactic acid may inhibit the supply of energy from astrocytes to neurons involved with memory formation. However, little is known about the effects of increased hind-gut fermentation due to changes in diet on circulating lactic acid concentrations and memory. METHOD: Thirty-six male Wistar rats were fed three dietary treatments: a commercial rat and mouse chow, a soluble carbohydrate based diet or a fermentable carbohydrate based diet. The parameters estimating memory were examined by employing the object recognition test. Physical parameters of fermentation including hind-gut and plasma lactic acid concentrations were examined after sacrifice, either 3 or 21h after feeding. RESULTS: Increased fermentation in the hind-gut of rats, indicated by lower caecum pH, was associated with increased plasma l-lactic acid (r=-0.41, p=0.020) and d-lactic acid (r=-0.33, p=0.087). Memory, being able to discriminate between a familiar and a novel object during the object recognition test, was reduced with increasing plasma d-lactic acid (r=-0.51, p=0.021). CONCLUSIONS: Memory impairment was associated with alterations in plasma d-lactic acid following the fermentation of carbohydrate in the hind-gut. Further work is still required to determine whether these effects are mediated centrally or via direct connections through the enteric nervous system. |
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Authors:
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T L Hanstock; P E Mallet; E H Clayton |
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Publication Detail:
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Type: Journal Article Date: 2010-10-01 |
Journal Detail:
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Title: Physiology & behavior Volume: 101 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 653-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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School of Behavioural, Cognitive and Social Sciences, University of New England, Armidale, NSW 2351, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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