| Increased Pancreatic Fat Fraction Is Present In Obese Adolescents With Metabolic Syndrome. | |
| | |
MedLine Citation:
|
PMID: 22157928 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES:: Very little is known about pancreatic fat accumulation and its possible associations with metabolic syndrome (MetS) and glucose metabolism. The aim of this study was to quantify pancreatic fat fraction (PFF) in lean and obese adolescents and explore its relationship with metabolic parameters. METHODS:: We recruited 25 lean and 24 obese adolescents. PFF and visceral fat (VAT) were determined using MRI. We measured blood pressure, fasting glucose, insulin, liver enzymes, leptin and lipids levels. Obese subjects underwent an oral glucose tolerance test. RESULTS:: PFF was significantly higher in obese than lean subjects (4.8 ± 1.2 vs. 3.6 ± 0.9; p < .001) and was associated with VAT, gamma-GT, triglycerides, HDL-cholesterol, leptin concentrations, and with MetS (p < 0.05 for all). None of the obese subjects had glucose intolerance, but when adjusted for VAT, the following 3 parameters correlated negatively with PFF: fasting, 30 and 120-minute insulin levels. We divided subjects into 3 groups: I) lean without MetS; II) obese without MetS and III) obese with MetS and observed that PFF increased gradually among groups (I: 3.56 ± 0.88; II: 4.70 ± 1.06; III: 5.34 ± 1.49 %; p < .001). CONCLUSIONS:: Obese adolescents accumulate fat in the pancreas. PFF correlates with the presence of MetS. Even in absence of glucose intolerance, pancreatic fat deposition is associated with impaired insulin response to glucose overload. This suggests that beta-cell dysfunction may already be present in non-diabetic obese adolescents, mirroring what has been shown in adults, and that pancreatic fat accumulation may participate in obesity-associated pancreatic endocrine dysfunction. |
| | |
Authors:
|
Albane B R Maggio; Pascal Mueller; Julie Wacker; Magalie Viallon; Dominique C Belli; Maurice Beghetti; Nathalie J Farpour-Lambert; Valérie A McLin |
Related Documents
:
|
21802578 - Macrovascular effects and safety issues of therapies for type 2 diabetes. 21274458 - Improving blood pressure control in patients with diabetes mellitus and high cardiovasc... 21695768 - Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis... 19021748 - Evolution of morphogenesis in 360-million-year-old conodont chordates calibrated in days. 1229808 - Decrease in whole blood viscosity in alloxan diabetic rabbits. 15311578 - The prevalence of diabetes and related services in missouri and missouri's progress tow... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
|
Title: Journal of pediatric gastroenterology and nutrition Volume: - ISSN: 1536-4801 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
*Pediatric sport medicine and obesity care program, Division of pediatric specialties, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, Switzerland †Pediatric Gastroenterology Unit, Ostschweizer Kinderspital, St.Gallen, Switzerland ‡Pediatric Cardiology Unit, Division of pediatric specialties, Department of Child and Adolescent, University Hospitals of Geneva and University of Geneva, Switzerland §Division of radiology, Dept of imaging and medical information sciences, University Hospitals of Geneva, Switzerland ||Pediatric Gastroenterology Unit, Division of pediatric specialties, Department of Child and Adolescent, University Hospitals of Geneva, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Resolution of Parenteral Nutrition Associated Jaundice on Changing From a Soya-Oil Emulsion to a Com...
Next Document: Ketamine With And Without Midazolam For Gastrointestinal Endoscopies In Children: A Randomized Sing...