Document Detail

Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants.
MedLine Citation:
PMID:  21402638     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine if infants with very low birth weight who receive packed red blood cell (PRBC) transfusions have increased odds of developing necrotizing enterocolitis (NEC), to determine the rate of NEC after PRBC transfusion, and to characterize the blood transfused preceding the onset of NEC.
STUDY DESIGN: A retrospective cohort design was used. The study population included infants with a birth weight of <1500 g who were from a single center. NEC after transfusion was defined as NEC that occurred in the 48 hours after initiation of PRBC transfusion. Statistical analysis included unadjusted and multivariable analyses.
RESULTS: The study sample included 2311 infants. A total of 122 infants (5.3%) developed NEC, and 33 (27%) of 122 NEC cases occurred after transfusion. NEC occurred after 33 (0.5%) of 6484 [corrected] transfusions. Infants who received a transfusion had increased adjusted odds (odds ratio: 2.3 [95% confidence interval: 1.2-4.2]) of developing NEC compared with infants who did not receive a transfusion. PRBCs transfused before NEC were predominantly (83%) from male donors and were a median of 5 days old.
CONCLUSIONS: In our study sample, PRBC transfusion was associated with increased odds of NEC. The rate of NEC after transfusion was 1.4%. From our data we could not determine if PRBC transfusions were part of the causal pathway for NEC or were indicative of other factors that may be causal for NEC.
David A Paul; Amy Mackley; Alexandra Novitsky; Yong Zhao; Alison Brooks; Robert G Locke
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Publication Detail:
Type:  Journal Article     Date:  2011-03-14
Journal Detail:
Title:  Pediatrics     Volume:  127     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-05-31     Revised Date:  2012-04-01    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  635-41     Citation Subset:  AIM; IM    
Section of Neonatology, Department of Pediatrics, Christiana Care Health System, 4745 Ogletown-Stanton Rd, MAP 1, Suite 217, Newark, DE 19713, USA.
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MeSH Terms
Anemia, Neonatal / epidemiology,  therapy*
Cohort Studies
Cross-Sectional Studies
Enterocolitis, Necrotizing / epidemiology,  etiology*
Erythrocyte Transfusion / adverse effects*,  statistics & numerical data
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / epidemiology,  etiology*
Infant, Very Low Birth Weight*
Intensive Care Units, Neonatal
Odds Ratio
Retrospective Studies
Risk Factors
Statistics as Topic
Erratum In:
Pediatrics. 2011 Sep;128(3):593-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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