| Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants. | |
| | |
MedLine Citation:
|
PMID: 21402638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To determine if infants with very low birth weight who receive packed red blood cell (PRBC) transfusions have increased odds of developing necrotizing enterocolitis (NEC), to determine the rate of NEC after PRBC transfusion, and to characterize the blood transfused preceding the onset of NEC. STUDY DESIGN: A retrospective cohort design was used. The study population included infants with a birth weight of <1500 g who were from a single center. NEC after transfusion was defined as NEC that occurred in the 48 hours after initiation of PRBC transfusion. Statistical analysis included unadjusted and multivariable analyses. RESULTS: The study sample included 2311 infants. A total of 122 infants (5.3%) developed NEC, and 33 (27%) of 122 NEC cases occurred after transfusion. NEC occurred after 33 (0.5%) of 6484 [corrected] transfusions. Infants who received a transfusion had increased adjusted odds (odds ratio: 2.3 [95% confidence interval: 1.2-4.2]) of developing NEC compared with infants who did not receive a transfusion. PRBCs transfused before NEC were predominantly (83%) from male donors and were a median of 5 days old. CONCLUSIONS: In our study sample, PRBC transfusion was associated with increased odds of NEC. The rate of NEC after transfusion was 1.4%. From our data we could not determine if PRBC transfusions were part of the causal pathway for NEC or were indicative of other factors that may be causal for NEC. |
| | |
Authors:
|
David A Paul; Amy Mackley; Alexandra Novitsky; Yong Zhao; Alison Brooks; Robert G Locke |
Related Documents
:
|
1657828 - The use of anti-d prophylaxis in the management of miscarriage in general practice. 19927408 - Death at work in america: pandemic, mostly unacknowledged. 21419878 - Enrollment experiences in a pediatric longitudinal observational study: the environment... 15322458 - Reenactment of circumstances in deaths related to restraint. 6723448 - Baby beautiful: adult attributions of infant competence as a function of infant attract... 22721748 - Mother-infant socioemotional contingent responding in families by adoption and birth. |
Publication Detail:
|
Type: Journal Article Date: 2011-03-14 |
Journal Detail:
|
Title: Pediatrics Volume: 127 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-04 Completed Date: 2011-05-31 Revised Date: 2012-04-01 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: 635-41 Citation Subset: AIM; IM |
Affiliation:
|
Section of Neonatology, Department of Pediatrics, Christiana Care Health System, 4745 Ogletown-Stanton Rd, MAP 1, Suite 217, Newark, DE 19713, USA. dpaul@christianacare.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Neonatal
/
epidemiology,
therapy* Cohort Studies Cross-Sectional Studies Delaware Enterocolitis, Necrotizing / epidemiology, etiology* Erythrocyte Transfusion / adverse effects*, statistics & numerical data Female Gestational Age Humans Infant, Newborn Infant, Premature, Diseases / epidemiology, etiology* Infant, Very Low Birth Weight* Intensive Care Units, Neonatal Male Odds Ratio Retrospective Studies Risk Factors Statistics as Topic |
| Comments/Corrections | |
Erratum In:
|
Pediatrics. 2011 Sep;128(3):593-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Growth standards of infants with Prader-Willi syndrome.
Next Document: Severe Vulvovaginitis as a Presenting Problem of Type 2 Diabetes in Adolescent Girls: A Case Series.