Document Detail


Increased Occurrence of Disorders of Sex Development, Prematurity and Intra Uterine Growth Restriction in Children with Proximal Hypospadias Associated with Undescended Testes.
MedLine Citation:
PMID:  23159278     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Proximal hypospadias represents 20% of hypospadias cases and are considered to have a higher incidence of associated urological, non-urological, developmental, Disorders of Sex Development and chromosomal anomalies. The aim of this study was to compare the occurrence of associated anomalies in boys with proximal hypospadias and undescended testis with boys with proximal hypospadias and descended testes. MATERIALS AND METHODS: The medical records of 69 boys who underwent a two-stage hypospadias repair for proximal hypospadias in a single institution over an eleven-year period (2001-2011) were reviewed. Collected data included; demographics, birth history, associated urological and extra-urological anomalies, karyotype analysis and gonad palpability. Patients were divided into two groups: Group 1 - patients with proximal hypospadias and undescended testis and Group 2 - patients with proximal hypospadias and descended testes. Statistical analysis was performed using a 2-tailed Fischer's Exact Test. RESULTS: There were 17 (25%) patients in Group 1 (median age 2.2yrs) and 52 (75%) in Group 2 (median age 2yrs). Children in Group 1 had a higher incidence of XY Non Dysgenetic Testicular DSD (8 in Group 1, 11 in Group 2, p=0.06), premature birth (9 in Group 1, 10 in Group 2, p=0.01) and intra-uterine growth restriction (8 in Group 1, 8 in Group 2, p=0.01). CONCLUSIONS: There is a significant association of prematurity and intra-uterine growth restriction with proximal hypospadias and undescended testis. In addition because of the high incidence (28%) of an underlying Disorder of Sex Development male infants with proximal hypospadias should have a multidisciplinary evaluation.
Authors:
P Sekaran; S O'Toole; M Flett; S Cascio
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Urology, Royal Hospital for Sick Children, Glasgow, Scotland, United Kingdom.
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