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Increased Neutrophil Count in Nascent Metabolic Syndrome.
MedLine Citation:
PMID:  23316866     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: The alarming increase in the prevalence of metabolic syndrome globally demands serious attention. Recently, we reported increased cellular dysfunction of subcutaneous adipose tissue and monocytes contributing to the insulin resistance and increased inflammation in nascent metabolic syndrome. The major circulating leukocyte is the neutrophil (polymorphonuclear neutrophil, PMN). The aim of the study was to evaluate leukocyte levels in nascent metabolic syndrome uncomplicated by diabetes or cardiovascular disease (CVD). Methods: In this study, we compared nascent metabolic syndrome (n=63) versus control subjects (n=44). Fasting blood was collected for complete blood count, insulin, glucose, high-sensitivity C-reactive protein (hsCRP), and nitrotyrosine. Results: The white blood cell (WBC) and neutrophil counts were significantly increased in metabolic syndrome compared to controls following adjustment for age, gender, and adiposity. There were significant correlations between neutrophil counts with homeostasis model assessment of insulin resistance (HOMA-IR) and hsCRP, (r=0.29, P=0.004 and r=0.35, P=0.0004, respectively). Similarly the correlations of WBC counts were significant with HOMA-IR and hsCRP (r=0.22, P=0.03 and r=0.31, P=0.0014, respectively). Conclusion: These findings suggest that significantly elevated WBCs due to increased neutrophil counts in nascent metabolic syndrome could contribute to the increased risk for both diabetes and CVD.
Authors:
Harmeet Kaur; Beverley Adams-Huet; Gerred Smith; Ishwarlal Jialal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-14
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  -     ISSN:  1557-8518     ISO Abbreviation:  Metab Syndr Relat Disord     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, and Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, University of California at Davis , Davis, California.
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