Document Detail


Increased metallothionein I/II expression in patients with temporal lobe epilepsy.
MedLine Citation:
PMID:  23028585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) and patients with TLE associated with tumor or dysplasia (TLE-TD) were evaluated for expression of MT-I/II, for the vesicular zinc levels, and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis, microgliosis and reduced neuronal population. In TLE-TD, the same changes were observed, except that were mainly confined to fascia dentata. Increased vesicular zinc was observed only in the inner molecular layer of MTLE patients, when compared to control cases. Correlation and linear regression analyses indicated an association between increased MT-I/II and increased astrogliosis in TLE. MT-I/II levels did not correlate with any clinical variables, but MTLE patients with secondary generalized seizures (SGS) had less MT-I/II than MTLE patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from TLE patients and our data suggest that it is associated with astrogliosis and may be associated with different seizure spread patterns.
Authors:
José Eduardo Peixoto-Santos; Orfa Yineth Galvis-Alonso; Tonicarlo Rodrigues Velasco; Ludmyla Kandratavicius; João Alberto Assirati; Carlos Gilberto Carlotti; Renata Caldo Scandiuzzi; Luciano Neder Serafini; João Pereira Leite
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-18
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-06     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44709     Citation Subset:  IM    
Affiliation:
Department of Neuroscience and Behavior, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto-São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Epilepsy, Temporal Lobe / metabolism*
Female
Fluorescent Antibody Technique
Hippocampus / metabolism
Humans
Immunohistochemistry
Male
Metallothionein / metabolism*
Middle Aged
Chemical
Reg. No./Substance:
9038-94-2/Metallothionein
Comments/Corrections

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