Document Detail

Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy.
MedLine Citation:
PMID:  22238156     Owner:  NLM     Status:  MEDLINE    
METHODS: Sixteen patients with unilateral temporal lobe epilepsy and 30 healthy subjects were studied with (11)C-PBR28 PET and MRI. Uptake of radioactivity after injection of (11)C-PBR28 was measured from regions of interest drawn bilaterally onto MR images. Brain uptake from ipsilateral and contralateral hemispheres was compared using a paired-samples t test.
RESULTS: We found that brain uptake was higher ipsilateral to the seizure focus in the hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and choroid plexus but not in other brain regions. This asymmetry was more pronounced in patients with hippocampal sclerosis than in those without.
CONCLUSION: We found increased uptake of radioactivity after injection of (11)C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy, suggesting increased expression of TSPO. Studies in larger samples are required to confirm this finding and determine the clinical utility of imaging TSPO in temporal lobe epilepsy.
Jussi Hirvonen; William C Kreisl; Masahiro Fujita; Irene Dustin; Omar Khan; Shmuel Appel; Yi Zhang; Cheryl Morse; Victor W Pike; Robert B Innis; William H Theodore
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-11
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  53     ISSN:  1535-5667     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-03-30     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-40     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Biological Transport
Case-Control Studies
Cerebrum / metabolism,  radionuclide imaging
Epilepsy, Temporal Lobe / metabolism*,  radionuclide imaging
Gene Expression Regulation*
Inflammation / metabolism
Middle Aged
Positron-Emission Tomography
Pyrimidines / diagnostic use,  metabolism
Receptors, GABA / metabolism*
Young Adult
Grant Support
1Z01-NS002236-34/NS/NINDS NIH HHS; Z01-MH-002852-04/MH/NIMH NIH HHS; Z99 MH999999/MH/NIMH NIH HHS
Reg. No./Substance:
0/(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine; 0/Biological Markers; 0/Pyrimidines; 0/Receptors, GABA; 0/TSPO protein, human

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