| Increased In Vivo Expression of an Inflammatory Marker in Temporal Lobe Epilepsy. | |
| | |
MedLine Citation:
|
PMID: 22238156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Animal studies and clinical observations suggest that epilepsy is associated with inflammation. Translocator protein (TSPO) (18 kDa), a marker of inflammation, is increased in vitro in surgical samples from patients with temporal lobe epilepsy. TSPO can be measured in the living human brain with PET and the novel radioligand (11)C-PBR28. In this study, we sought to determine whether in vivo expression of TSPO is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy. METHODS: Sixteen patients with unilateral temporal lobe epilepsy and 30 healthy subjects were studied with (11)C-PBR28 PET and MRI. Uptake of radioactivity after injection of (11)C-PBR28 was measured from regions of interest drawn bilaterally onto MR images. Brain uptake from ipsilateral and contralateral hemispheres was compared using a paired-samples t test. RESULTS: We found that brain uptake was higher ipsilateral to the seizure focus in the hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and choroid plexus but not in other brain regions. This asymmetry was more pronounced in patients with hippocampal sclerosis than in those without. CONCLUSION: We found increased uptake of radioactivity after injection of (11)C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy, suggesting increased expression of TSPO. Studies in larger samples are required to confirm this finding and determine the clinical utility of imaging TSPO in temporal lobe epilepsy. |
| | |
Authors:
|
Jussi Hirvonen; William C Kreisl; Masahiro Fujita; Irene Dustin; Omar Khan; Shmuel Appel; Yi Zhang; Cheryl Morse; Victor W Pike; Robert B Innis; William H Theodore |
Related Documents
:
|
18810206 - Tissue changes after radiosurgery for vestibular schwannomas. 18321106 - Emissive terbium probe for multiphoton in vitro cell imaging. 16524356 - Science fiction becomes enlightening reality: diagnostic scans. 11541396 - Changes in the central nervous system during long-duration space flight: implications f... 3941846 - Surgical anatomy and blood supply of the fascial layers of the temporal region. 19379966 - Factors affecting interest in cardiothoracic surgery: survey of north american general ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: - ISSN: 1535-5667 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; and. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intramyocardial hematoma with epicardial rupture following percutaneous coronary intervention.
Next Document: The role of the oligosaccharide binding cleft of rice BGlu1 in hydrolysis of cellooligosaccharides a...