Document Detail

Increased IMP content in glycogen-depleted muscle fibres during submaximal exercise in man.
MedLine Citation:
PMID:  3227908     Owner:  NLM     Status:  MEDLINE    
To study the relationship between glycogen depletion and IMP accumulation in different fibre types, single fibres were dissected from biopsies taken at rest and after one hour of exercise at 70% of maximal oxygen uptake. These fibres were analysed histochemically for glycogen and fibre types and pooled into classes of type I or type II fibres with low, medium or high glycogen content, in a total of six classes. These pools were analysed for ATP, ADP, AMP and IMP contents by high performance liquid chromatography. The contents of ATP, ADP and AMP at rest, and immediately after exercise, were not significantly different between the six fibre classes. The IMP content in glycogen-depleted fibres obtained after exercise was, however, higher than in pools of glycogen-filled fibres obtained both at rest and after exercise. In conclusion, the elevated IMP content in glycogen-depleted but not in glycogen-filled type I and type II muscle fibres during prolonged submaximal exercise indicates a decreased ATP regeneration rate in glycogen-depleted fibres, which may be a factor limiting exercise duration during prolonged submaximal exercise.
B Norman; A Sollevi; E Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  133     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1988 May 
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM; S    
Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Adenosine Triphosphate / metabolism
Glycogen / metabolism*
Inosine Monophosphate / metabolism*
Inosine Nucleotides / metabolism*
Muscles / metabolism*
Oxygen Consumption
Physical Exertion*
Reg. No./Substance:
0/Inosine Nucleotides; 131-99-7/Inosine Monophosphate; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 9005-79-2/Glycogen

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