Document Detail


Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.
MedLine Citation:
PMID:  18403025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). In MS, myeloid dendritic cells (mDCs) secrete elevated amounts of IL-23, a potent proinflammatory cytokine, compared to healthy donors. Here, we examined the role of CD46, a complement binding factor, in mDCs by analyzing cytokine and chemokine production in healthy donors and patients with MS. There were striking differences between these groups with increased IL-23p19, CCL3 and CCL5 production, but decreased CCL2 levels in patients. This demonstrates major differences of DC activation upon CD46 activation, with a potential role in the pathogenesis of MS.
Authors:
Adi Vaknin-Dembinsky; Gopal Murugaiyan; David A Hafler; Anne L Astier; Howard L Weiner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-04-10
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  195     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-07-10     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD46 / genetics,  metabolism*
Chemokines / metabolism*
Dendritic Cells / drug effects,  metabolism*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-23 / secretion*
Lipopolysaccharides / pharmacology
Lymphocyte Activation
Male
Middle Aged
Multiple Sclerosis / drug therapy,  pathology*
Statistics, Nonparametric
Grant Support
ID/Acronym/Agency:
NS23132/NS/NINDS NIH HHS; R01 NS023132/NS/NINDS NIH HHS; R01 NS023132-17/NS/NINDS NIH HHS; R01 NS023132-18/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD46; 0/Chemokines; 0/Interleukin-23; 0/Lipopolysaccharides
Comments/Corrections

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