| Increased IGF-1 levels in an elderly population in relation to heart failure and cardiovascular mortality. Impact of ACE-inhibitors. | |
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MedLine Citation:
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PMID: 21976623 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AbstractObjective. There are conflicting results regarding the association of circulating insulin-like growth factor-1 (IGF-1) with cardiovascular (CV) morbidity and mortality. We assessed the relationship between IGF-1 levels and heart failure (HF), ischemic heart disease (IHD) and CV mortality in an elderly population taking into account the possible impact of angiotensin- converting enzyme inhibitors (ACE-inhibitors).Design and methods. 851 persons aged 66-81 years, in a rural Swedish municipality were evaluated by medical history, clinical examination, electrocardiography, echocardiography and fasting plasma samples. They were then followed for 8 years.Results and conclusion. Patients on ACE-inhibitors had elevated IGF-1 levels compared to those without.In patients on ACE-inhibitors higher IGF-1 values were found in those with an EF<40% compared to EF≥40%, in those with higher pro-BNP levels in quartile 4 versus 1, and in patients with IHD when compared to those without (p<0.001). In patients without ACE-inhibitors, no relationship was found between IGF-1 levels and HF or IHD. In multivariate regression only ACE-inhibitors, EKG-changes characteristic for IHD and gender had a significant impact on IGF-1.Persons with higher IGF-1 levels in quintiles 4 and 5 compared to quintiles 1 and 2 had a 50% higher risk for cardiovascular death (p=0.03). This was significant after adjustment for well-known CV risk factors and ACE-inhibitors (p=0.03).Our results show that treatment with ACE-inhibitors in an elderly population is associated with increased IGF-1 levels especially in patients with impaired cardiac function or IHD. High IGF-1 levels tend to be associated with an increased risk for CV mortality.Keywords. Insulin-like growth factor-1, heart failure, ischemic heart disease, elderly population. |
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Authors:
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Simona I Chisalita; Ulf Dahlström; Hans J Arnqvist; Urban Alehagen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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S Chisalita, Department of Acute Health Care, Linköping, 58535, Sweden. |
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