Document Detail


Increased Gene Expression of the Cardiac Endothelin System in Obese Mice.
MedLine Citation:
PMID:  25181417     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obesity is a well-known risk factor of atherosclerosis and heart failure. In the human heart, a local endothelin system containing prepro-endothelin-1, endothelin-converting enzyme-1, and endothelin receptors A and B has been described. The endothelin system is activated in heart failure; however, the impact of obesity on the cardiac endothelin system is unknown. In this study, 18-week-old male C57BL/6 mice fed either a control diet or a high-fat diet for 10 weeks were analyzed. High-fat diet significantly increased the body weight of the animals and augmented low-density lipoprotein, high-density lipoprotein, and cholesterol plasma levels, compared to control. The animal groups showed no significant differences in left ventricular size or function (heart rate, ejection fraction, fractional shortening, left ventricular posterior wall thickness, cardiac output) after control or high-fat diet. We did not observe signs of cardiac hypertrophy or changes in markers of cardiac fibrosis in these heart samples. The cardiac expression of prepro-endothelin-1 mRNA, endothelin-converting enzyme-1 mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight (p<0.05 vs. control). Furthermore, endothelin-1 plasma levels showed an increasing trend. In conclusion, an increased expression of genes of the endothelin system was observed in the hearts of 18-week-old mice after high-fat diet, possibly contributing to later cardiovascular complications of obesity.
Authors:
R A Catar; G Muller; A Brandt; H Langbein; C Brunssen; C Goettsch; A Frenzel; A Hofmann; W Goettsch; N Steinbronn; R H Strasser; U Schubert; B Ludwig; S R Bornstein; H Morawietz
Related Documents :
11042017 - Baseline corticosterone peaks in shorebirds with maximal energy stores for migration: a...
12421007 - Recycling spent larval food of corcyra cephalonica stainton as a broiler feed ingredient.
8165157 - The utilization of sodium in sodium zeolite a by broilers.
17179417 - Influence of pediococcus-based probiotic on coccidiosis in broiler chickens.
2399267 - Blood pressure and serum lipids from shr after diets supplemented with evening primrose...
24018277 - Meat quality of buffalo young bulls fed faba bean as protein source.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-2
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme     Volume:  -     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice.
Next Document:  Osteoprotegerin, Fibroblast Growth Factor 23, and Vitamin D3 Levels in Male Patients with Hypogonadi...