| Increased ERG a- and b-wave amplitudes in 7- to 10-year-old children resulting from prenatal lead exposure. | |
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MedLine Citation:
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PMID: 12037016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the dose-response relationship between blood lead concentration ([PbB]) and scotopic ERG amplitude in 7- to 10-year-old children with lifetime lead exposure. METHODS: Full-field flash scotopic ERGs were recorded over a 4-log-unit range in 45 dark-adapted children with normal visual acuity. [PbB] was measured throughout pregnancy and postnatal development, and the subjects' [PbB] levels were grouped at each age by tertiles. RESULTS: The median [PbB] during pregnancy was, from lowest to highest tertile, 2.5 to 5.0, 7.5 to 9.0, and 14.0 to 16.5 microg/dL, and after birth was 4.0 to 8.0, 6.0 to 14.5, and 7.5 to 21.0 microg/dL. Only maternal [PbB] at 12 weeks of pregnancy showed a significant dose-response relationship with the ERG measures, so that with increasing [PbB] there were significant increases in leading-edge a-wave amplitude, peak a-wave amplitude, and b-wave amplitude and sensitivity, with no changes in implicit times. Data analyses showed that children whose mothers had [PbB] of 10.5 microg/dL or more at 12 weeks of pregnancy had relatively increased a- and b-waves. CONCLUSIONS: Lead exposure during the first trimester of pregnancy produces dose-dependent increases in scotopic a- and b-wave amplitudes in 7- to 10-year-old children. The results suggest that the increases in a- and b-wave amplitudes originate from rods; however, the increased b-wave amplitude and sensitivity may also originate in the inner retina. These alterations occurred at maternal [PbB] at or below currently accepted safe levels. These novel findings reveal that the developing retina is a sensitive target for lead and suggest that lead-exposed children be examined for possible future visual system deficits. |
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Authors:
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Stephen J Rothenberg; Lourdes Schnaas; Manuel Salgado-Valladares; Esther Casanueva; Andrew M Geller; H Kenneth Hudnell; Donald A Fox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 43 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-30 Completed Date: 2002-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2036-44 Citation Subset: IM |
Affiliation:
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National Institute of Public Health, Cuernavaca, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Dose-Response Relationship, Drug Electroretinography / drug effects* Female Humans Iron / blood Lead / adverse effects*, blood Male Maternal Exposure / adverse effects* Photic Stimulation Pregnancy Prenatal Exposure Delayed Effects* Prospective Studies Retina / drug effects*, physiology Vitamin A / blood Zinc / blood |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A; 7439-89-6/Iron; 7439-92-1/Lead; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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