Document Detail


Increased ERG a- and b-wave amplitudes in 7- to 10-year-old children resulting from prenatal lead exposure.
MedLine Citation:
PMID:  12037016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine the dose-response relationship between blood lead concentration ([PbB]) and scotopic ERG amplitude in 7- to 10-year-old children with lifetime lead exposure. METHODS: Full-field flash scotopic ERGs were recorded over a 4-log-unit range in 45 dark-adapted children with normal visual acuity. [PbB] was measured throughout pregnancy and postnatal development, and the subjects' [PbB] levels were grouped at each age by tertiles. RESULTS: The median [PbB] during pregnancy was, from lowest to highest tertile, 2.5 to 5.0, 7.5 to 9.0, and 14.0 to 16.5 microg/dL, and after birth was 4.0 to 8.0, 6.0 to 14.5, and 7.5 to 21.0 microg/dL. Only maternal [PbB] at 12 weeks of pregnancy showed a significant dose-response relationship with the ERG measures, so that with increasing [PbB] there were significant increases in leading-edge a-wave amplitude, peak a-wave amplitude, and b-wave amplitude and sensitivity, with no changes in implicit times. Data analyses showed that children whose mothers had [PbB] of 10.5 microg/dL or more at 12 weeks of pregnancy had relatively increased a- and b-waves. CONCLUSIONS: Lead exposure during the first trimester of pregnancy produces dose-dependent increases in scotopic a- and b-wave amplitudes in 7- to 10-year-old children. The results suggest that the increases in a- and b-wave amplitudes originate from rods; however, the increased b-wave amplitude and sensitivity may also originate in the inner retina. These alterations occurred at maternal [PbB] at or below currently accepted safe levels. These novel findings reveal that the developing retina is a sensitive target for lead and suggest that lead-exposed children be examined for possible future visual system deficits.
Authors:
Stephen J Rothenberg; Lourdes Schnaas; Manuel Salgado-Valladares; Esther Casanueva; Andrew M Geller; H Kenneth Hudnell; Donald A Fox
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  43     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-30     Completed Date:  2002-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2036-44     Citation Subset:  IM    
Affiliation:
National Institute of Public Health, Cuernavaca, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Child
Dose-Response Relationship, Drug
Electroretinography / drug effects*
Female
Humans
Iron / blood
Lead / adverse effects*,  blood
Male
Maternal Exposure / adverse effects*
Photic Stimulation
Pregnancy
Prenatal Exposure Delayed Effects*
Prospective Studies
Retina / drug effects*,  physiology
Vitamin A / blood
Zinc / blood
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A; 7439-89-6/Iron; 7439-92-1/Lead; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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