Document Detail


Increased EEG delta frequency corresponds to chorioamnionitis-related brain injury.
MedLine Citation:
PMID:  20036959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the impact of chorioamnionitis on the intrapartal EEG delta frequency in the non-anesthetized preterm sheep. 10 mg intra-amniotic LPS or saline were given 2 or 14 days before preterm birth at gestational day 125. Lambs were delivered by Caesarean section under local anesthesia. A 5-minute EEG depicted delta activity and amplitude, and the relationship between EEG delta activity and both the white matter (WM) and cortical microglial activation and apoptosis was analyzed. EEG delta activity was increased significantly in the 14-day LPS preterm fetuses compared to both preterm control and 2-day LPS animals (p less than 0.05). No differences were seen between controls and the 2-day LPS fetuses. A direct association was demonstrated between EEG delta activity and both cortical microglial activation (r = 0,645, p = 0,024) and apoptosis (r = 0,580, p = 0,048), and between delta and WM activated microglia (r = 0,742, p = 0,006) and apoptosis (r = 0,777, p = 0,003). This study is the first to show a relationship between brain dysfunction and chorioamnionitis-related injury at birth.
Authors:
Antonio Wenceslao Danilo Gavilanes; Markus Gantert; Eveline Strackx; Luc J Zimmermann; Saskia Seeldrayers; Johan S H Vles; Boris W Kramer
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Publication Detail:
Type:  Journal Article     Date:  2010-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  2     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Maastricht University Medical Center, School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands. danilo.gavilanes@mumc.nl
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Apoptosis / physiology
Biological Markers*
Brain / physiopathology*
Chorioamnionitis / diagnosis*,  pathology*
Delta Rhythm*
Female
Flow Cytometry
Microglia / physiology
Pregnancy
Premature Birth
Sheep
Chemical
Reg. No./Substance:
0/Biological Markers

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