Document Detail

Increased D-dimer levels in twin gestation.
MedLine Citation:
PMID:  10899347     Owner:  NLM     Status:  MEDLINE    
In normal pregnancy, the hemostatic balance is displaced toward hypercoagulability. The elevation in plasma levels of coagulation factors VII, VIII, and X and fibrinogen and the increased concentrations of plasminogen activator inhibitors [1,2] may predispose individuals to thromboembolism, especially near term [1,3]. Because human multifetal gestation requires still greater physiological alterations, the imbalance in hemostasis is further exaggerated. It has been suggested that the changes in the coagulation system near term may even mimic low-grade disseminated intravascular coagulopathy [4]. However, for the majority of women with multifetal gestation, the coagulopathy observed in the laboratory is not clinically apparent [5]. Despite the large body of research on the physiological adaptation to pregnancy, relatively little is known of the biological adaptation in general and the hemostatic changes in particular associated with multiple gestation.
J Bar; D Blickstein; M Hod; I Bar-Hava; Z Ben-Rafael; J Rahmany-Babai; J Lahav
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  98     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-15     Completed Date:  2000-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
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MeSH Terms
Antifibrinolytic Agents / immunology,  metabolism
Blood Coagulation Tests
Fibrin Fibrinogen Degradation Products / immunology,  metabolism*
Fibrinogen / metabolism
Latex Fixation Tests
Pregnancy Trimester, Third / blood
Pregnancy, Multiple / blood*
Statistics, Nonparametric
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 9001-32-5/Fibrinogen

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