| Increased D-dimer levels in twin gestation. | |
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MedLine Citation:
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PMID: 10899347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In normal pregnancy, the hemostatic balance is displaced toward hypercoagulability. The elevation in plasma levels of coagulation factors VII, VIII, and X and fibrinogen and the increased concentrations of plasminogen activator inhibitors [1,2] may predispose individuals to thromboembolism, especially near term [1,3]. Because human multifetal gestation requires still greater physiological alterations, the imbalance in hemostasis is further exaggerated. It has been suggested that the changes in the coagulation system near term may even mimic low-grade disseminated intravascular coagulopathy [4]. However, for the majority of women with multifetal gestation, the coagulopathy observed in the laboratory is not clinically apparent [5]. Despite the large body of research on the physiological adaptation to pregnancy, relatively little is known of the biological adaptation in general and the hemostatic changes in particular associated with multiple gestation. |
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Authors:
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J Bar; D Blickstein; M Hod; I Bar-Hava; Z Ben-Rafael; J Rahmany-Babai; J Lahav |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis research Volume: 98 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-11-15 Completed Date: 2000-11-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 485-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel. jbar@clalit.org.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antifibrinolytic Agents / immunology, metabolism Blood Coagulation Tests Female Fibrin Fibrinogen Degradation Products / immunology, metabolism* Fibrinogen / metabolism Humans Latex Fixation Tests Pregnancy Pregnancy Trimester, Third / blood Pregnancy, Multiple / blood* Statistics, Nonparametric Twins |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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