Document Detail

Increased Cortical Excitability with Prefrontal High-Frequency Repetitive Transcranial Magnetic Stimulation in Adolescents with Treatment-Resistant Major Depressive Disorder.
MedLine Citation:
PMID:  22257125     Owner:  NLM     Status:  Publisher    
Abstract Objective: To examine changes in motor cortical excitability in adolescent subjects receiving 30 sessions of high-frequency prefrontal repetitive transcranial magnetic stimulation (rTMS). Methods: Eight adolescents with treatment-resistant major depressive disorder (MDD) enrolled in an open augmentation trial of 10 Hz rTMS. Resting motor thresholds were obtained by the visualization of movement method with a maximum likelihood threshold hunting computer algorithm at baseline and after every five sessions of rTMS. Motor threshold was recorded as the percentage of total machine output at each measurement. Results: Motor threshold data from baseline, weeks 2, 4, and 5 were included in a mixed model repeated measure analysis to examine a change in least square mean effect over time. The omnibus effect did not reach statistical significance (F=1.25, p=0.32). However, multiple comparisons from the overall model demonstrated a decrease in the least square mean motor threshold. The mean contrast from baseline to week 5 approached significance (p=0.07). Moreover, a post-hoc analysis with a Wilcoxon signed ranks test demonstrated a significant decrease at week 5 (p=0.03). Conclusions: This suggests that high-frequency rTMS may increase cortical excitability in adolescents with treatment-resistant MDD.
Paul E Croarkin; Christopher A Wall; Paul A Nakonezny; Jeylan S Buyukdura; Mustafa M Husain; Shirlene M Sampson; Graham J Emslie; F Andrew Kozel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-18
Journal Detail:
Title:  Journal of child and adolescent psychopharmacology     Volume:  -     ISSN:  1557-8992     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105358     Medline TA:  J Child Adolesc Psychopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Division of Child and Adolescent Psychiatry, Department of Psychiatry, UT Southwestern Medical Center Dallas , Dallas, Texas.
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