| Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. | |
| | |
MedLine Citation:
|
PMID: 20943784 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
CONTEXT: Plasma YKL-40 is elevated in patients with type 2 diabetes. The potential role of visceral adipose tissue (VAT) as a significant source of YKL-40 is unknown. OBJECTIVE: In the study circulating and expression levels of YKL-40 were examined in VAT analyzing the contribution of adipocytes and stromovascular fraction cells (SVFCs). We also explored YKL-40's implication in insulin resistance and inflammation and the effect of weight loss on plasma YKL-40 concentrations. PATIENTS AND METHODS: Samples obtained from 53 subjects were used in the study. Gene and protein expression levels of YKL-40 were analyzed in VAT as well as in both adipocytes and SVFCs. In addition, circulating YKL-40 concentrations were measured before and after weight loss achieved either by Roux-en-Y gastric bypass (n = 26) or after a conventional dietetic program (n = 20). RESULTS: Circulating concentrations and VAT expression of YKL-40 were increased in obese patients with type 2 diabetes (P < 0.01) as well as associated with variables of insulin resistance and inflammation. No differences in YKL-40 expression levels between adipocytes and SVFCs were detected. Monocyte chemoattractant protein-1 and homeostasis model assessment emerged (P < 0.01) as independent factors predicting circulating YKL-40. Elevated levels of YKL-40 in obese patients decreased after weight loss following a conventional hypocaloric diet (P < 0.05) but not via a surgery-induced negative energy balance mediated by the Roux-en-Y gastric bypass. CONCLUSIONS: The association of increased YKL-40 mRNA and protein levels in VAT with its circulating concentrations indicates an important contribution of VAT in YKL-40 regulation. Furthermore, our data suggest a relevant role of glucose metabolism and inflammation on YKL-40 regulation. |
| | |
Authors:
|
Victoria Catalán; Javier Gómez-Ambrosi; Amaia Rodríguez; Beatriz Ramírez; Fernando Rotellar; Victor Valentí; Camilo Silva; María J Gil; Javier Salvador; Gema Frühbeck |
Related Documents
:
|
18393104 - Sirtuins: novel targets for metabolic disease. 18778784 - Physiological levels of insulin and igf-1 synergistically enhance the differentiation o... 18996284 - White adipose tissue as endocrine organ and its role in obesity. 18974244 - Adipose inflammation, insulin resistance, and cardiovascular disease. 3159594 - Incorporation of [3h]thymidine into myocardial capillary cells in streptozotocin-diabet... 19325354 - The effects of the pentoxifylline on survival of the skin flaps in streptozotocin-diabe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-13 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 96 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 200-9 Citation Subset: AIM; IM |
Affiliation:
|
Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain. vcatalan@unav.es |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of diseas...
Next Document: Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, ...