Document Detail

Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.
MedLine Citation:
PMID:  21325490     Owner:  NLM     Status:  MEDLINE    
The clinical picture of herpes simplex virus type 2 (HSV-2) infection includes genital blisters and less frequently meningitis, and some individuals suffer from recurrent episodes of these manifestations. We hypothesized that adaptive and/or innate immune functional deficiencies may be a major contributing factor in susceptibility to recurrent HSV-2 meningitis. Ten patients with recurrent HSV-2 meningitis were studied during clinical remission. For comparison, 10 patients with recurrent genital HSV infections as well as 21 HSV-seropositive and 19 HSV-seronegative healthy blood donors were included. HSV-specific T cell blasting and cytokine secretion were evaluated in whole blood cultures. HSV-2-induced NK cell gamma interferon production, dendritic cell Toll-like receptor (TLR) expression, and TLR agonist-induced alpha interferon secretion were analyzed. Patients with recurrent HSV-2 meningitis had elevated T cell blasting and Th1 and Th2 cytokine production in response to HSV antigens compared to those of patients with recurrent genital infections. A somewhat increased NK cell response, increased dendritic cell expression of TLR3 and -9, and increased TLR-induced alpha interferon responses were also noted. Contrary to our expectation, recurrent HSV-2 meningitis patients have increased HSV-specific adaptive and innate immune responses, raising the possibility of immune-mediated pathology in the development of recurrent HSV2 meningitis.
Elisabeth Franzen-Röhl; Danika Schepis; Maria Lagrelius; Kristina Franck; Petra Jones; Jan-Åke Liljeqvist; Tomas Bergström; Elisabeth Aurelius; Klas Kärre; Louise Berg; Hans Gaines
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-16
Journal Detail:
Title:  Clinical and vaccine immunology : CVI     Volume:  18     ISSN:  1556-679X     ISO Abbreviation:  Clin. Vaccine Immunol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-08     Completed Date:  2011-07-25     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101252125     Medline TA:  Clin Vaccine Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden.
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MeSH Terms
Cytokines / secretion
Dendritic Cells / immunology
Gene Expression
Herpes Simplex / immunology*
Herpesvirus 2, Human / immunology*
Immunity, Cellular*
Killer Cells, Natural / immunology
Meningitis, Viral / immunology*
Middle Aged
T-Lymphocytes / immunology
Toll-Like Receptors / immunology
Reg. No./Substance:
0/Cytokines; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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