Document Detail


Increased CD3 positive cells in bronchoalveolar lavage fluid after hydrogen fluoride inhalation.
MedLine Citation:
PMID:  10505658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study examined whether experimental hydrogen fluoride exposure for 1 hour induces an inflammatory response in the lower respiratory tract that is detectable in bronchoalveolar lavage fluid. METHODS: Nineteen healthy, nonsmoking men were exposed for 1 hour to constant low (<0.6 mg/m3), intermediate (0.7-2.4 mg/m3), or high (2.5-5.2 mg/m3) concentrations of hydrogen fluoride. Bronchoalveolar lavage was performed at least 3 weeks before and 24 hours after the exposure. For 15 subjects differential countings were performed. RESULTS: There was a significant increase in the percentage of CD3 positive cells in the bronchial portion for those exposed to "intermediate" and "high" concentrations. For the "high" exposure group the increase in the bronchoalveolar portion was also significant. A significant correlation was found between the increase in the percentage of lymphocytes and CD3 positive cells in the bronchoalveolar portion (Spearman's coefficient r=0.68, P=0.008). Myeloperoxidase and interleukin-6 increased significantly in the bronchial portion for those exposed to "high" concentrations. There was a significant increase in myeloperoxidase (P=0.005) for all the exposures, while there was a decrease in E-selectin (P=0.007). CONCLUSIONS: Hydrogen fluoride may induce an inflammatory reaction in the airways at concentrations that can occur in the ambient air in the primary aluminum industry.
Authors:
K Lund; M Refsnes; T Sandstrøm; P Søstrand; P Schwarze; J Boe; J Kongerud
Related Documents :
22417138 - Obesity: a disease or a biological adaptation? an update.
16841188 - For my wellness, not just my illness: north americans' use of dietary supplements.
8550858 - The effect of a commercially available triclosan-containing toothpaste compared to a so...
23517298 - Hydrogen peroxide mediates endothelium-dependent dilation of coronary arterioles in obe...
23980738 - Associations among evening snacking, screen time, weight status, and overall diet quali...
21401898 - Relationship between nonalcoholic fatty liver disease and metabolic syndrome.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  25     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  326-34     Citation Subset:  IM    
Affiliation:
Department of Thoracic Medicine, The National Hospital, University of Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD3 / analysis*
Bronchoalveolar Lavage Fluid / chemistry*
Cell Count
Humans
Hydrofluoric Acid / pharmacology*
Male
Prospective Studies
Chemical
Reg. No./Substance:
0/Antigens, CD3; 7664-39-3/Hydrofluoric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mortality from nonmalignant diseases of the respiratory, genitourinary and nervous systems among wor...
Next Document:  Asthma in tunnel workers exposed to synthetic resins.