| Increased ACE and decreased ACE2 expression in kidneys from patients with IgA nephropathy. | |
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MedLine Citation:
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PMID: 20689326 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Angiotensin-converting enzyme (ACE)2 forms angiotensin-1-7 which may protect kidney in a counterregulatory manner to angiotensin II. Recent studies revealed increased ACE and decreased ACE2 expression in kidneys of patients with diabetic nephropathy. However, these changes may not be specific for diabetic nephropathy. We studied ACE and ACE2 expression in patients with IgA nephropathy. METHODS: Renal ACE and ACE2 expression was assessed by immunohistochemistry and in situ hybridization in 30 patients with IgA nephropathy and 21 healthy controls. Correlation between ACE and ACE2 expression and levels of various biochemical parameters was also assessed. Gene expression was also assessed in minimal change nephrotic syndrome (MCNS) and membranous nephropathy (MN) as disease controls. RESULTS: Reduced ACE2 expression (p < 0.01) and increased ACE expression in glomeruli (p < 0.001), and reduced ACE2 expression in tubulointerstitium (p < 0.001) were observed in patients with IgA nephropathy compared to healthy controls, although the changes in ACE2 mRNA were not statistically significant. Reduced renal ACE2 expression was also found in MN but not in MCNS. Correlation between renal ACE and ACE2 expression and proteinuria was not observed in IgA nephropathy. CONCLUSION: IgA nephropathy is associated with increased ACE and decreased ACE2 expression in kidneys, as in diabetic nephropathy. |
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Authors:
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Sonoo Mizuiri; Hiromichi Hemmi; Michitsune Arita; Toshiyuki Aoki; Yasushi Ohashi; Moriatsu Miyagi; Ken Sakai; Kazutoshi Shibuya; Hiroki Hase; Atsushi Aikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-04 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 117 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c57-66 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Nephrology, Toho University School of Medicine, Ohta-ku, Tokyo, Japan. sm210@med.toho-u.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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