Document Detail

Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure.
MedLine Citation:
PMID:  18840939     Owner:  NLM     Status:  MEDLINE    
Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
Daniela Pelclová; Zdenka Fenclová; Petr Kacer; Marek Kuzma; Tomás Navrátil; Jindriska Lebedová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Industrial health     Volume:  46     ISSN:  1880-8026     ISO Abbreviation:  Ind Health     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  484-9     Citation Subset:  IM    
1st Medical Faculty, Department of Occupational Medicine, Charles University of Prague, Prague, Czech Republic.
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MeSH Terms
Aged, 80 and over
Asbestos / metabolism*,  poisoning*
Asbestosis / metabolism*
Biological Markers / analysis
Breath Tests / methods
Case-Control Studies
Dinoprost / analogs & derivatives*,  analysis,  metabolism
Middle Aged
Occupational Exposure
Oxidative Stress
Risk Assessment
Reg. No./Substance:
0/Biological Markers; 1332-21-4/Asbestos; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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