| Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure. | |
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MedLine Citation:
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PMID: 18840939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases. |
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Authors:
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Daniela Pelclová; Zdenka Fenclová; Petr Kacer; Marek Kuzma; Tomás Navrátil; Jindriska Lebedová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Industrial health Volume: 46 ISSN: 1880-8026 ISO Abbreviation: Ind Health Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-08 Completed Date: 2009-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985065R Medline TA: Ind Health Country: Japan |
Other Details:
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Languages: eng Pagination: 484-9 Citation Subset: IM |
Affiliation:
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1st Medical Faculty, Department of Occupational Medicine, Charles University of Prague, Prague, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Asbestos / metabolism*, poisoning* Asbestosis / metabolism* Biological Markers / analysis Breath Tests / methods Case-Control Studies Dinoprost / analogs & derivatives*, analysis, metabolism Female Humans Male Middle Aged Occupational Exposure Oxidative Stress Prognosis Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 1332-21-4/Asbestos; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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