Document Detail


Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure.
MedLine Citation:
PMID:  18840939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8+/-1.7 yr and mean duration of asbestos exposure 24.1+/-2.0 yr. The control group had 46 subjects with mean age 65.2+/-3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography-electrospray ionization-mass spectrometry, was higher in asbestos-exposed subjects (69.5+/-6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0+/-7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
Authors:
Daniela Pelclová; Zdenka Fenclová; Petr Kacer; Marek Kuzma; Tomás Navrátil; Jindriska Lebedová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Industrial health     Volume:  46     ISSN:  1880-8026     ISO Abbreviation:  Ind Health     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-08     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  484-9     Citation Subset:  IM    
Affiliation:
1st Medical Faculty, Department of Occupational Medicine, Charles University of Prague, Prague, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Asbestos / metabolism*,  poisoning*
Asbestosis / metabolism*
Biological Markers / analysis
Breath Tests / methods
Case-Control Studies
Dinoprost / analogs & derivatives*,  analysis,  metabolism
Female
Humans
Male
Middle Aged
Occupational Exposure
Oxidative Stress
Prognosis
Risk Assessment
Chemical
Reg. No./Substance:
0/Biological Markers; 1332-21-4/Asbestos; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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