| Increased 6-hydroxycortisol excretion in pregnant women: implication of drug-metabolizing enzyme induction. | |
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MedLine Citation:
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PMID: 2260334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of pregnancy on hepatic drug-metabolizing enzyme activity was investigated in nine healthy pregnant women using the ratio of 6-hydroxycortisol (6-OHF), to total 17-hydroxycorticosteroid (17-OHCS) in 24-hour urine as an index of the hepatic monooxygenase activity. The values of 6-OHF and the ratio (713 +/- 250 micrograms/d and 0.323 +/- 0.242; mean +/- SD) before delivery were significantly higher than they were during early puerperium (395 +/- 145 micrograms/d and 0.114 +/- 0.055) and approximately three months after delivery (237 +/- 67 micrograms/d and 0.066 +/- 0.034). Although the values three months after delivery were comparable to those found in the nonpregnant group (n = 10; 228 +/- 48 micrograms/d and 0.081 +/- 0.031), 6-OHF values one week after delivery were significantly higher than those observed in the control group. These observations suggest that drug-metabolizing enzyme induction may occur during pregnancy. |
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Authors:
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C Ohkita; M Goto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: DICP : the annals of pharmacotherapy Volume: 24 ISSN: 1042-9611 ISO Abbreviation: DICP Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1991-01-28 Completed Date: 1991-01-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8904338 Medline TA: DICP Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 814-6 Citation Subset: IM |
Affiliation:
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Department of Hospital Pharmacy, Tenri Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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17-Hydroxycorticosteroids
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urine Adolescent Adult Endoplasmic Reticulum / enzymology Enzyme Induction Female Humans Hydrocortisone / analogs & derivatives*, urine Liver / cytology, enzymology Mixed Function Oxygenases / biosynthesis* Pregnancy / urine* |
| Chemical | |
Reg. No./Substance:
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0/17-Hydroxycorticosteroids; 50-23-7/Hydrocortisone; 53-35-0/6 beta-hydroxycortisol; EC 1.-/Mixed Function Oxygenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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