Document Detail

Increased 6-hydroxycortisol excretion in pregnant women: implication of drug-metabolizing enzyme induction.
MedLine Citation:
PMID:  2260334     Owner:  NLM     Status:  MEDLINE    
The effect of pregnancy on hepatic drug-metabolizing enzyme activity was investigated in nine healthy pregnant women using the ratio of 6-hydroxycortisol (6-OHF), to total 17-hydroxycorticosteroid (17-OHCS) in 24-hour urine as an index of the hepatic monooxygenase activity. The values of 6-OHF and the ratio (713 +/- 250 micrograms/d and 0.323 +/- 0.242; mean +/- SD) before delivery were significantly higher than they were during early puerperium (395 +/- 145 micrograms/d and 0.114 +/- 0.055) and approximately three months after delivery (237 +/- 67 micrograms/d and 0.066 +/- 0.034). Although the values three months after delivery were comparable to those found in the nonpregnant group (n = 10; 228 +/- 48 micrograms/d and 0.081 +/- 0.031), 6-OHF values one week after delivery were significantly higher than those observed in the control group. These observations suggest that drug-metabolizing enzyme induction may occur during pregnancy.
C Ohkita; M Goto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  DICP : the annals of pharmacotherapy     Volume:  24     ISSN:  1042-9611     ISO Abbreviation:  DICP     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-28     Completed Date:  1991-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904338     Medline TA:  DICP     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  814-6     Citation Subset:  IM    
Department of Hospital Pharmacy, Tenri Hospital, Japan.
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MeSH Terms
17-Hydroxycorticosteroids / urine
Endoplasmic Reticulum / enzymology
Enzyme Induction
Hydrocortisone / analogs & derivatives*,  urine
Liver / cytology,  enzymology
Mixed Function Oxygenases / biosynthesis*
Pregnancy / urine*
Reg. No./Substance:
0/17-Hydroxycorticosteroids; 50-23-7/Hydrocortisone; 53-35-0/6 beta-hydroxycortisol; EC 1.-/Mixed Function Oxygenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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