| Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 22295989 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SUMMARY AT A GLANCE: The expression of cholesterol 25-hydroxylase was up-regulated in the lungs of COPD patients. There was excessive production of 25-hydroxycholesterol in the airways of COPD patients and 25-hydroxycholesterol concentrations in the airways were associated with reduced lung function, elevated neutrophil counts and high IL-8 levels in sputum. ABSTRACT: Background and objective: 25-Hydroxycholesterol (25-HC) is produced from cholesterol by the enzyme, cholesterol 25-hydroxylase, and is associated with atherosclerosis of vessels. Recently, 25-HC was reported to cause inflammation in various types of tissues. The aim of this study was to assess the production of 25-HC in the airways and to elucidate the role of 25-HC in neutrophil infiltration in the airways of patients with COPD. Methods: Eleven control never-smokers, six control ex-smokers without COPD, and 13 COPD patients participated in the lung tissue study. The expression of cholesterol 25-hydroxylase in the lung was investigated. Twelve control subjects and 17 patients with COPD also participated in the sputum study. The concentrations of 25-HC in sputum were quantified by liquid chromatography (LC)/mass spectrometry (MS)/MS analysis. To elucidate the role of 25-HC in neutrophilic inflammation of the airways, the correlation between 25-HC levels and neutrophil counts in sputum was investigated. Results: The expression of cholesterol 25-hydroxylase was significantly enhanced in lung tissue from COPD patients compared with that from control subjects. Cholesterol 25-hydroxylase was localized in alveolar macrophages and pneumocytes of COPD patients. The concentration of 25-HC in sputum was significantly increased in COPD patients, and was inversely correlated with percent of predicted FVC, FEV1 and DLCO. The concentrations of 25-HC in sputum were significantly correlated with sputum IL-8 levels and neutrophil counts. Conclusions: 25-HC production was enhanced in the airways of COPD patients and may play a role in neutrophilic inflammation. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
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Authors:
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Hisatoshi Sugiura; Akira Koarai; Tomohiro Ichikawa; Yoshiaki Minakata; Kazuto Matsunaga; Tsunahiko Hirano; Keiichiro Akamatsu; Satoru Yanagisawa; Makoto Furusawa; Yumiko Uno; Masashi Yamasaki; Yoshinori Satomi; Masakazu Ichinose |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: Respirology (Carlton, Vic.) Volume: - ISSN: 1440-1843 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616368 Medline TA: Respirology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology. |
Affiliation:
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Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Takeda Pharmaceutical Company Ltd., Osaka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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