| Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. | |
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MedLine Citation:
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PMID: 22308941 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Obesity is associated with a low grade inflammation which contributes to the development of insulin resistance and diabetes. The aim of this study was to assess the total saturated (SFAs), monounsaturated (MUFAs) and polyunsaturated fatty acids (PUFAs) in plasma from asymptomatic obese subjects and to determine the arachidonic/eicosapentanoic acid ratio [ARA/EPA] as a marker of inflammation, and its eventual association with ultrasensitive CRP. Fourteen obese (34.4 +/- 11.1y.; BMI: 36.0 +/- 4,5 kg/m2) and 12 normal-weight (30.6 +/- 7.8y.; BMI: 23,6 +/- 2,4 kg/m2) subjects were recruited and their plasma fatty acids were determined by gas chromatography. usCRP was higher in the obese subjects (p = 0.01) and correlates with their body fat content. The percentages of SFAs, MUFAs, PUFAs were not affected in the obese subjects but their concentrations were increased, compared with the control group. However, no differences in the long chain PUFAs (DHA and EPA) concentrations or in the plasmatic ARA/EPA ratio were observed in these subjects. These observations do not support a relation between the ARA/EPA ratio and the presence of low grade inflammation evaluated by plasma usCRP in this group of asymptomatic obese subjects. |
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Authors:
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Jerusa Brignardello; Pamela Morales; Erik Diaz; Oscar Brunser; Martin Gotteland |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archivos latinoamericanos de nutrición Volume: 61 ISSN: 0004-0622 ISO Abbreviation: Arch Latinoam Nutr Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2012-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067507 Medline TA: Arch Latinoam Nutr Country: Venezuela |
Other Details:
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Languages: eng Pagination: 149-53 Citation Subset: IM |
Affiliation:
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Laboratory of Microbiology and Probiotics, Institute of Nutrition and Food Technology (INTA), Univ. of Chile, Santiago, Chile. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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