Document Detail


Increase of myocardial inhibitory G-proteins in catecholamine-refractory septic shock or in septic multiorgan failure.
MedLine Citation:
PMID:  7847435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of the study was to investigate the mechanisms of myocardial catecholamine refractoriness in septic shock. METHODS: The inhibitory guanine nucleotide-binding proteins (Gi alpha) were studied with pertussis toxin labeling and radioimmunologically in myocardium from patients who died while in catecholamine-refractory septic shock and from patients who died of noncardiac disease. RESULTS: An increase by 62% (immunological Gi alpha) and 221% (pertussis toxin substrate) of myocardial Gi alpha was observed in patients with catecholamine-refractory shock compared with controls. The increases of Gi alpha were greater than those found in chronic heart failure reported earlier. CONCLUSIONS: An increase in the expression of Gi alpha could also be important in conditions other than chronic heart failure, eg, septic shock. An increase of Gi alpha could play a pathophysiologically relevant role in catecholamine refractoriness in septic shock and could provide a target for pharmacologic treatment in this condition.
Authors:
M Böhm; R Kirchmayr; P Gierschik; E Erdmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  98     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-07     Completed Date:  1995-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine III, University of Cologne, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Autopsy
Autoradiography
Catecholamines / therapeutic use*
Drug Resistance
GTP-Binding Proteins / metabolism*
Humans
Middle Aged
Multiple Organ Failure / drug therapy,  metabolism*,  microbiology
Myocardium / metabolism*
Pertussis Toxin
Radioimmunoassay
Shock, Septic / drug therapy,  metabolism*,  microbiology
Virulence Factors, Bordetella
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Virulence Factors, Bordetella; EC 2.4.2.31/Pertussis Toxin; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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