| Increase of lifespan for glioma-bearing rats by using minibeam radiation therapy. | |
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MedLine Citation:
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PMID: 22186645 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This feasibility work assesses the therapeutic effectiveness of minibeam radiation therapy, a new synchrotron radiotherapy technique. In this new approach the irradiation is performed on 9L gliosarcoma-bearing rats with arrays of parallel beams of width 500-700 µm. Two irradiation configurations were compared: a lateral unidirectional irradiation and two orthogonal arrays interlacing at the target. A dose escalation study was performed. A factor of three gain in the mean survival time obtained for some animals paves the way for further exploration of the different possibilities of this technique and its further optimization. |
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Authors:
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Yolanda Prezado; Sukhena Sarun; Silvia Gil; Pierre Deman; Audrey Bouchet; Geraldine Le Duc |
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Publication Detail:
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Type: Journal Article Date: 2011-11-25 |
Journal Detail:
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Title: Journal of synchrotron radiation Volume: 19 ISSN: 1600-5775 ISO Abbreviation: J Synchrotron Radiat Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9888878 Medline TA: J Synchrotron Radiat Country: Denmark |
Other Details:
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Languages: eng Pagination: 60-5 Citation Subset: IM |
Affiliation:
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ID17 Biomedical Beamline, European Synchrotron Radiation Facility, 6 Rue Jules Horowitz, BP 220, 38043 Grenoble Cedex, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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