Document Detail

Increase of isoprostane 8-epi-PGF(2alpha)after restarting smoking.
MedLine Citation:
PMID:  11427039     Owner:  NLM     Status:  MEDLINE    
Isoprostanes are known as reliable markers of in vivo oxidation injury. Cigarette smoking has been shown to be associated with a significant increase in 8-epi-PGF(2alpha), a major member of this family of compounds. Quitting smoking reduces 8-epi-PGF(2alpha) values to normal within a couple of weeks only. In this follow-up we checked the 8-epi-PGF(2alpha), values in plasma, serum and urine in 28 people who restarted smoking after a quitting attempt of various duration. 8-epi-PGF(2alpha)shows a certain increase after restarting smoking reaching a maximum after already 1 week. Continuation of smoking does not significantly further increase 8-epi-PGF(2alpha). These data indicate a fast response of restarting as on quitting smoking on in vivo oxidation injury. The oxidation injury reflected by 8-epi-PGF(2alpha)may be a key pathogenetic mechanism in smoking-induced vascular injury.
F Chehne; A Oguogho; G Lupattelli; A C Budinsky; B Palumbo; H Sinzinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  64     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-27     Completed Date:  2001-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  307-10     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Department of Nuclear Medicine, University of Vienna, A-1090 Vienna, Austria.
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MeSH Terms
Arteriosclerosis / blood,  urine
Biological Markers / blood,  urine
Dinoprost* / analogs & derivatives*
F2-Isoprostanes / blood*,  urine*
Hypercholesterolemia / blood,  urine
Hypertension / blood,  urine
Middle Aged
Oxidative Stress
Smoking / adverse effects*,  blood,  urine
Smoking Cessation
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/F2-Isoprostanes; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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