| Increase in tissue and circulating pentraxin3 levels in patients with aortic valve stenosis. | |
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MedLine Citation:
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PMID: 20934563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammation is involved in the pathogenesis of nonrheumatic aortic valve stenosis (AS). Pentraxin3 (PTX3) is produced at the inflammatory site; however, tissue and circulating PTX3 levels in patients with AS remain largely unknown. METHODS: We enrolled 84 patients who received aortic replacement surgery due to AS (n = 53) or aortic regurgitation (AR; n = 31). PTX3 expression in aortic valves was evaluated in patients with AS and AR by immunohistochemistry and Western blot analysis. We further investigated circulating PTX3 and high-sensitivity C-reactive protein levels in patients with AS, AR, and age-matched controls. RESULTS: Immunohistochemical and Western blot analyses revealed that PTX3 was expressed in aortic valves. PTX3 expression was increased in AS valves compared with control and AR valves. Strong PTX3 immunoreactivity was found particularly in macrophages of AS valves. Plasma PTX3 levels were increased in patients with AS than in those with AR and controls, while serum high-sensitivity C-reactive protein levels did not differ among three groups. Moreover, plasma PTX3 levels were positively correlated with the amounts of PTX3 expression in aortic valves. CONCLUSIONS: We demonstrated for the first time that tissue and plasma PTX3 levels were increased in patients with AS. These findings suggest that PTX3 may participate in the pathophysiology of AS. |
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Authors:
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Yoshiro Naito; Takeshi Tsujino; Hirokuni Akahori; Mitsumasa Ohyanagi; Masataka Mitsuno; Yuji Miyamoto; Hiroyuki Hao; Seiichi Hirota; Tohru Masuyama |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 160 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 685-91 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. ynaito@hyo-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins Adult Aged Aged, 80 and over Aortic Valve / metabolism*, ultrasonography Aortic Valve Stenosis / metabolism*, surgery, ultrasonography Biological Markers / metabolism Blotting, Western C-Reactive Protein / metabolism* Disease Progression Echocardiography, Doppler, Color Enzyme-Linked Immunosorbent Assay Female Heart Valve Prosthesis* Humans Immunohistochemistry Male Middle Aged Prognosis Serum Amyloid P-Component / metabolism* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Biological Markers; 0/Serum Amyloid P-Component; 148591-49-5/PTX3 protein; 9007-41-4/C-Reactive Protein |
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