Document Detail

Increase in spleen volume of rats on experimental model of pre-hepatic portal hypertension.
MedLine Citation:
PMID:  24190379     Owner:  NLM     Status:  Publisher    
BACKGROUND: Pressure increase in the portal venous system, caused by reduction of blood supply to the liver, develops collateral circulation of splanchnic vessel that reaches the venous system of superior vena cava. The spleen works as an auxiliary capacitance system which compensates the increase in portal pressure that may cause splenomegaly.
AIM: To reproduce experimental model of pre-hepatic portal hypertension by reducing the caliber of the vein, allowing the study of alterations in the rat's spleen in this situation.
METHODS: Fifteen Wistar rats were divided into three groups of five. All animals were operated, being the first five used as control (group 1) and reoperated after 15 days (sham-operated), along with five other animals had portal hypertension induced (group 2). The last five animals, also with portal hypertension were reoperated after 30 days (group 3). Prehepatic portal hypertension was caused in experimental animals by partial ligation of portal vein in hepatic hilum. The spleen was measured during the first and second operations, allowing the calculation of its volume in the three groups studied using specific mathematical formula.
RESULTS: No macroscopic changes in spleen were significant when compared the animals reoperated after 15 days (group 2) to the ones after 30 days (group 3), being 15 days considered enough for the evaluation of effects on spleen after partial ligation. Although the volume of spleens studied in groups 2 and 3 have increased after the first operation - ranging on average from 0.5417 cm³ to 0.6345 cm³ at reoperation with increase of approximately 17% in volume between the first and second phase - the rsults were not statistically significant (p> 0.05).
CONCLUSION: There was no statistically significant increase in the spleen volume after partial ligation of the portal vein when comparing the calculated volume in the first operation to the volume found at reoperation. There was no difference when comparing the spleen volumes of the animals reoperated after 15 days and the ones reoperated after 30 days.
Aline Riquena da Silva; Ricardo José Kriguer-Júnior; Leonardo Carvalho Serigiolle; Helbert Minuncio Pereira Gomes; Daren Athiê Boy Rodrigues; Pedro Luiz Squilacci Leme
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Publication Detail:
Journal Detail:
Title:  Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery     Volume:  26     ISSN:  0102-6720     ISO Abbreviation:  Arq Bras Cir Dig     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100283     Medline TA:  Arq Bras Cir Dig     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  206-212     Citation Subset:  -    
Vernacular Title:
Aumento do volume do baço em modelo experimental de hipertensão portal pré-hepática em ratos.
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