Document Detail

Increase in sister chromatid exchange rates in association with occupational exposure to N,N-dimethylformamide.
MedLine Citation:
PMID:  1399017     Owner:  NLM     Status:  MEDLINE    
The effects of occupational exposure to N,N-dimethylformamide (DMF) on sister chromatid exchange (SCE) rates were studied in peripheral lymphocytes from 22 DMF-exposed women (aged 22-52 years) in comparison with 22 sex-, age-, and residence-matched controls. All subjects were nonsmokers and nondrinkers as confirmed by medical interview. The 22 pairs were divided by the intensity of exposure to DMF into 3 subgroups of high-exposed (8 pairs with mean DMF exposure at 5.8 ppm), middle-exposed (5 pairs with DMF at 0.7 ppm in combination with toluene at 0.9 ppm), and low-exposed (9 pairs with DMF at 0.3 ppm). The SCE rates were significantly higher in the high (P less than 0.005) and middle (P less than 0.01) exposed than in their matched pairs, and the increase was related to the intensity of DMF exposure.
K Seiji; O Inoue; S X Cai; T Kawai; T Watanabe; M Ikeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  64     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-06     Completed Date:  1992-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  65-7     Citation Subset:  IM    
Tohoku Rosai Hospital, Sendai, Japan.
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MeSH Terms
Case-Control Studies
Dimethylformamide / analysis,  pharmacology*
Lymphocytes / drug effects
Middle Aged
Occupational Exposure* / analysis
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:

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