Document Detail


Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients.
MedLine Citation:
PMID:  23024286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in the pathogenesis of AE. Nevertheless, the precise causes of AE-associated barrier dysfunction are largely unknown. In this study, a comprehensive analysis of ceramide composition and lipid organization in nonlesional SC of AE patients and control subjects was performed by means of mass spectrometry, infrared spectroscopy, and X-ray diffraction. In addition, the skin barrier and clinical state of the disease were examined. The level of ceramides with an extreme short chain length is drastically increased in SC of AE patients, which leads to an aberrant lipid organization and a decreased skin barrier function. Changes in SC lipid properties correlate with disease severity but are independent of filaggrin mutations. We demonstrate for the first time that changes in ceramide chain length and lipid organization are directly correlated with the skin barrier defects in nonlesional skin of AE patients. We envisage that these insights will provide a new therapeutic entry in therapy and prevention of AE.
Authors:
Michelle Janssens; Jeroen van Smeden; Gert S Gooris; Wim Bras; Guiseppe Portale; Peter J Caspers; Rob J Vreeken; Thomas Hankemeier; Sanja Kezic; Ron Wolterbeek; Adriana P Lavrijsen; Joke A Bouwstra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-28
Journal Detail:
Title:  Journal of lipid research     Volume:  53     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-04-25     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2755-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Ceramides / chemistry,  metabolism*
Dermatitis, Atopic / genetics,  metabolism*
Female
Genotype
Humans
Intermediate Filament Proteins / genetics
Lipid Metabolism*
Male
Molecular Structure
Mutation
Chemical
Reg. No./Substance:
0/Ceramides; 0/Intermediate Filament Proteins; 0/filaggrin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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