Document Detail

Increase in the severity of allergic-type bronchospasm in sensitized and challenged cats treated with cortisone.
MedLine Citation:
PMID:  591103     Owner:  NLM     Status:  MEDLINE    
The feline model of immediate hypersensitivity to intraperitoneal ovalbumin sensitization, followed 65 days later by intravenous challenge, was used in this study to determine the effect of cortisone acetate administration on the severity of allergic bronchospasm. Cortisone acetate given intramuscularly prior to, during and immediately after sensitization increased the severity of the allergic response. Comparison of the respiratory, blood pressure and heart rate responses in cortisone-treated animals with nontreated controls indicated a significantly increased challenge reaction among the treated group. Of 7 cats receiving cortisone treatment, 5 died during the 30-min challenge monitoring period. None of the nontreated control group died. It is hypothesized that cortisone treatment impaired the activity of the cortisone-sensitive thymus-derived (T) cells.
M W Talbott; H R Strausser
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  55     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Bronchial Spasm / immunology*
Cortisone / pharmacology*
Heart Rate / drug effects
Hypersensitivity, Immediate / immunology,  mortality
Respiratory Function Tests
Reg. No./Substance:

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