| Increase in the severity of allergic-type bronchospasm in sensitized and challenged cats treated with cortisone. | |
MedLine Citation:
|
PMID: 591103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The feline model of immediate hypersensitivity to intraperitoneal ovalbumin sensitization, followed 65 days later by intravenous challenge, was used in this study to determine the effect of cortisone acetate administration on the severity of allergic bronchospasm. Cortisone acetate given intramuscularly prior to, during and immediately after sensitization increased the severity of the allergic response. Comparison of the respiratory, blood pressure and heart rate responses in cortisone-treated animals with nontreated controls indicated a significantly increased challenge reaction among the treated group. Of 7 cats receiving cortisone treatment, 5 died during the 30-min challenge monitoring period. None of the nontreated control group died. It is hypothesized that cortisone treatment impaired the activity of the cortisone-sensitive thymus-derived (T) cells. |
Authors:
|
M W Talbott; H R Strausser |
Related Documents
:
|
1599633 - A comprehensive review of the salt and blood pressure relationship. 6392163 - A double-blind randomized clinical study of the safety, tolerability and efficacy of he... 10026313 - Preservation of postural control of transient lower oesophageal sphincter relaxations i... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: International archives of allergy and applied immunology Volume: 55 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1977 |
Date Detail:
|
Created Date: 1978-02-23 Completed Date: 1978-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 395-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Bronchial Spasm / immunology* Cats Cortisone / pharmacology* Female Heart Rate / drug effects Hypersensitivity, Immediate / immunology, mortality Male Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
|
53-06-5/Cortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A new well-characterized, purified allergen preparation from timothy pollen. II. Allergenic in vivo ...
Next Document: A new well-characterized, purified allergen preparation from timothy pollen. III. Immunological prop...