Document Detail

Increase in serum alpha-fetoprotein without recurrent disease after hepatectomy for hepatocellular carcinoma.
MedLine Citation:
PMID:  7520014     Owner:  NLM     Status:  MEDLINE    
The case of a 58-year-old man with clinically-stable and compensated HBsAg-positive liver cirrhosis is reported. In April 1991, the patient underwent partial hepatectomy to treat a solitary 3.5 cm hepatocellular carcinoma (HCC), (Edmonson scale I), in the 5th liver segment. His serum alpha-fetoprotein (AFP) level was 24 ng/ml. After hepatectomy, the AFP level dropped to 8 ng/ml, but between the 4th and 12th month it rose gradually from 72 ng/ml to 4,520 ng/ml. Hepatic recurrence of HCC was excluded, but a 6 cm solitary metastasis (Edmonson scale III-IV) was detected on the right adrenal. Adrenalectomy was performed and two months later the patient is doing well and his AFP level is 51 ng/ml. The methodological approach to diagnosis, treatment and follow-up of HCC, and the relationship between AFP and liver and metastatic HCC, are discussed.
A Cristani; G Cioni; M De Santis; L Chianese; G Gozzetti; E Ventura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  41     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-13     Completed Date:  1994-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  137-9     Citation Subset:  IM    
Clinica Medica III, University of Modena, Italy.
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MeSH Terms
Adrenal Gland Neoplasms / blood,  secondary,  surgery
Carcinoma, Hepatocellular / blood*,  secondary,  surgery
Liver Neoplasms / blood*,  pathology,  surgery
Middle Aged
Neoplasm Recurrence, Local
alpha-Fetoproteins / metabolism*
Reg. No./Substance:

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