Document Detail


Increase in the response to adrenocorticotrophin of isolated maternal adrenal cells from sheep in late pregnancy.
MedLine Citation:
PMID:  6253584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenal cells were prepared from non-pregnant (anoestrous) sheep, from ewes at days 50, 100 and 130 of pregnancy and at term, and from animals at 1-5 days post partum. The ability of the cells to respond to adrenocorticotrophin (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), or combinations of these peptides has been examined in vitro. There was a progressive rise in the basal output of cortisol during pregnancy and in the absence of adrenocorticotrophin the cortisol output from adrenal cells of late pregnant and post-partum sheep the amount of ACTH required to produce half the maximum output of steroid (ED50) was 8 pg/ml. The ED50 increased in early pregnancy to 112 pg/ml and then fell to < 5 pg/ml between day 100 and term. At term both the stimulation ratio and the absolute increment in cortisol output elicited by a maximal concentration of ACTH were greater than at any other time tested in pregnant or non-pregnant sheep. Cortisol output during pregnancy was not increased by alpha-MSH, although at term the stimulatory effect of ACTH1-24 was partially antagonized by alpha-MSH. These results suggest that there may be an increase in the responsiveness of the maternal adrenal during pregnancy, although the factor(s) responsible remains unknown.
Authors:
J A Glickman; J E Patrick; J R Challis
Related Documents :
7383464 - Prenatal diagnosis of congenital adrenal hyperplasia.
9355804 - Immunolocalisation of p450(c17) in the fetal sheep adrenal gland during gestation and i...
21459374 - Transvaginal versus transabdominal ultrasound guidance for embryo transfer in donor ooc...
1399264 - Isolation and characterization of glycosylated and non-glycosylated prolactins from all...
16412004 - Non-invasive first trimester determination of fetal gender: a new approach for prenatal...
17261644 - Predictive value of maternal angiogenic factors in second trimester pregnancies with ab...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  86     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / cytology,  drug effects,  secretion*
Adrenocorticotropic Hormone / pharmacology*
Anestrus
Animals
Cells, Cultured
Female
Hydrocortisone / secretion*
Melanocyte-Stimulating Hormones / pharmacology
Pregnancy
Sheep
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9002-79-3/Melanocyte-Stimulating Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Correlation of cyclic AMP and cyclic GMP accumulation and steroidogenesis during stimulation of bovi...
Next Document:  Distribution of adrenocorticotrophic and lipotrophic peptides in the rat.