Document Detail

Increase in the response to adrenocorticotrophin of isolated maternal adrenal cells from sheep in late pregnancy.
MedLine Citation:
PMID:  6253584     Owner:  NLM     Status:  MEDLINE    
Adrenal cells were prepared from non-pregnant (anoestrous) sheep, from ewes at days 50, 100 and 130 of pregnancy and at term, and from animals at 1-5 days post partum. The ability of the cells to respond to adrenocorticotrophin (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), or combinations of these peptides has been examined in vitro. There was a progressive rise in the basal output of cortisol during pregnancy and in the absence of adrenocorticotrophin the cortisol output from adrenal cells of late pregnant and post-partum sheep the amount of ACTH required to produce half the maximum output of steroid (ED50) was 8 pg/ml. The ED50 increased in early pregnancy to 112 pg/ml and then fell to < 5 pg/ml between day 100 and term. At term both the stimulation ratio and the absolute increment in cortisol output elicited by a maximal concentration of ACTH were greater than at any other time tested in pregnant or non-pregnant sheep. Cortisol output during pregnancy was not increased by alpha-MSH, although at term the stimulatory effect of ACTH1-24 was partially antagonized by alpha-MSH. These results suggest that there may be an increase in the responsiveness of the maternal adrenal during pregnancy, although the factor(s) responsible remains unknown.
J A Glickman; J E Patrick; J R Challis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  86     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / cytology,  drug effects,  secretion*
Adrenocorticotropic Hormone / pharmacology*
Cells, Cultured
Hydrocortisone / secretion*
Melanocyte-Stimulating Hormones / pharmacology
Reg. No./Substance:
50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9002-79-3/Melanocyte-Stimulating Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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