Document Detail

Increase in pulmonary capillary permeability in dogs exposed to 100% O2.
MedLine Citation:
PMID:  3182483     Owner:  NLM     Status:  MEDLINE    
Changes in pulmonary capillary filtration induced by hyperoxia were investigated in 15 dogs. After 12 h of normobaric hyperoxic exposure, animals were anesthetized and artificially ventilated with 100% O2. A pulmonary lymphatic vessel was cannulated, and lymph flow and protein content were measured together with pulmonary and systemic hemodynamics. An increase in pulmonary capillary filtration was found when compared with reference data (normoxic dogs in similar conditions) gathered from available literature: lymph flow increased from 21.8 +/- 13.4 to 125.2 +/- 131.6 microliter/min, and the lymph-to-plasma protein concentration ratio increased from 0.67 +/- 0.08 to 0.78 +/- 0.08. To characterize the mechanisms involved, left atrial pressure was increased in two stages (approximately 10 and approximately 25 mmHg). The results clearly indicated an increase in pulmonary capillary permeability as evidenced by a decrease of the minimal estimate of the protein reflection coefficient from 0.62 +/- 0.05 to 0.42 +/- 0.05.
F Royer; D J Martin; G Benchetrit; F A Grimbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  65     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-12-07     Completed Date:  1988-12-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1140-6     Citation Subset:  IM    
Laboratoire de Physiologie, Faculté de Médecine de Grenoble, La Tronche, France.
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MeSH Terms
Blood Pressure
Capillary Permeability*
Lung / physiology
Lymph / metabolism,  secretion
Proteins / metabolism
Pulmonary Circulation*
Pulmonary Edema / etiology
Water-Electrolyte Balance
Reg. No./Substance:
0/Proteins; 7782-44-7/Oxygen

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