| Increase in the production of interleukin-10 early after implantation is related to the success of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 11775007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PROBLEM: To study the correlation of interleukin (IL)-10, IL-11 leukemia inhibitory factor (LIF), placental growth factor (PIGF), and transforming growth factor (TGF)-beta and outcome of human pregnancy. METHOD OF STUDY: We prospectively measured the serum levels of these cytokines in patients undergoing in vitro fertilization (IVF) programs. A total of 60 women (non-pregnant, n = 27; early abortions, n = 12; normal pregnancies, n = 21) were enrolled. RESULTS: There was no difference in the cytokines studied on D0 and D14 among the three groups of women. The increase in PIGF from D0 to D14 after human chorionic gonadotropin (hCG) injection was greater in pregnant women than in non-pregnant women; however, the difference did not reach significance (P = 0.068). The increase in IL-10 production from D14 to D21 was significant in women with successful pregnancies compared to women in the abortion group. CONCLUSIONS: This increase in IL-10 may be important in sustaining a normal pregnancy early after implantation. |
| | |
Authors:
|
M Y Wu; H F Chen; S U Chen; K H Chao; Y S Yang; H N Ho |
Related Documents
:
|
1377707 - Glycosylation changes in human chorionic gonadotropin and free alpha subunit as gestati... 15905817 - First trimester bleeding evaluation. 8694017 - Evidence of cis-trans isomerization of 9-cis-beta-carotene during absorption in humans. 15516387 - Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defini... 15368497 - Majewski osteodysplastic primordial dwarfism type ii (mopd ii): natural history and cli... 3653497 - Management of pregnancy in mothers with spina bifida. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 46 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2001 Dec |
Date Detail:
|
Created Date: 2001-12-31 Completed Date: 2002-07-01 Revised Date: 2009-11-25 |
Medline Journal Info:
|
Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 386-92 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, College of Medicine and the Hospital National Taiwan University, Taipei. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Embryo Implantation
/
immunology* Female Fertilization in Vitro Growth Inhibitors / biosynthesis Humans Interleukin-10 / biosynthesis* Interleukin-11 / biosynthesis Interleukin-6* Leukemia Inhibitory Factor Lymphokines / biosynthesis Pregnancy Pregnancy Outcome* Pregnancy Proteins / biosynthesis Prospective Studies Transforming Growth Factor beta / biosynthesis Transforming Growth Factor beta1 |
| Chemical | |
Reg. No./Substance:
|
0/Growth Inhibitors; 0/Interleukin-11; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 0/Pregnancy Proteins; 0/TGFB1 protein, human; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 130068-27-8/Interleukin-10; 144589-93-5/placenta growth factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunoprotection of gonads and genital tracts in human embryos and fetuses: immunohistochemical stud...
Next Document: Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and...