| Increase in plasma renin activity evoked by fenoldopam in dogs is directly mediated by dopamine1 receptor stimulation. | |
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MedLine Citation:
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PMID: 2472522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In anesthetized dogs, a 15-min intravenous (i.v.) infusion of fenoldopam (2.0 micrograms/kg/min) produced a decrease in mean aortic blood pressure (MAP) and an increase in renal blood flow (RBF) and plasma renin activity (PRA). The hypotensive effect attained a maximum within 5 min and then waned by approximately 30% at the end of fenoldopam administration. The development of this "tolerance" phenomenon was prevented by enalapril or saralasin. The hypotension and the increase in PRA were not modified by either propranolol or chlorisondamine but were inhibited by SCH 23390, a DA1 antagonist. Fenoldopam (0.1 microgram/kg/min for 15 min) infused into the left renal artery (i.a.) in intact or ganglion-blocked dogs did not change MAP but increased PRA. This effect was antagonized by SCH 23390. In ganglion-blocked preparations in which an apparently maximal renal vasodilatation had been achieved by an i.a. acetylcholine, i.a. fenoldopam produced an increase in PRA which was again blocked by SCH 23390. In uninephrectomized dogs, blockade of alpha- and beta-adrenoceptors or inhibition of renal baroreceptor and macula densa mechanisms of renin release failed to prevent the fenoldopam-induced increase in PRA. In conclusion, the release of renin by fenoldopam is responsible for the development of tolerance to the hypotensive effects of fenoldopam. Furthermore, because the increase in PRA was blocked by SCH 23390 and occurred in the absence of either operational systemic or intrarenal regulatory mechanisms, we propose that it is mediated by stimulation of specific dopamine (DA1) receptors on the juxtaglomerular (JG) cells. |
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Authors:
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F Montier; P Katchadourian; J Pratz; I Cavero |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 13 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-09 Completed Date: 1989-08-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 739-47 Citation Subset: IM |
Affiliation:
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Rhône-Poulenc Santé, Centre de Recherche de Vitry, Vitry-sur-Seine, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Benzazepines / pharmacology* Blood Pressure / drug effects Chlorisondamine / pharmacology Dogs Enalapril / pharmacology Female Fenoldopam Heart Rate / drug effects Indomethacin / pharmacology Injections, Intravenous Male Prazosin / pharmacology Propranolol / pharmacology Receptors, Dopamine / drug effects* Renal Circulation / drug effects Renin / blood* Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Receptors, Dopamine; 19216-56-9/Prazosin; 51-84-3/Acetylcholine; 525-66-6/Propranolol; 53-86-1/Indomethacin; 67227-56-9/Fenoldopam; 75847-73-3/Enalapril; 7701-62-4/Chlorisondamine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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