Document Detail


Increase in plasma levels of oxidized low-density lipoproteins in patients with coronary spastic angina.
MedLine Citation:
PMID:  11166780     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidized low-density lipoproteins (LDL) impair endothelium-dependent dilation and constrict arteries. This study examined possible relation of the circulating plasma levels of Ox-LDL to coronary spastic angina (CSA). The plasma levels of Ox-LDL were measured by ELISA in 37 consecutive patients with CSA and normal coronary angiograms and in 79 consecutive control patients. The Ox-LDL levels in patients with CSA were significantly higher than those in controls. In multivariate analysis, higher levels of Ox-LDL were a risk factor for CSA independently of other traditional risk factors. The Ox-LDL levels had a significant and positive correlation with constrictor response of coronary arteries to the intracoronary acetylcholine infusion. Thus, Ox-LDL may play a possible role in pathogenesis of coronary spasm.
Authors:
K Kugiyama; S Sugiyama; H Soejima; H Kawano; T Sakamoto; K Takazoe; H Ogawa; H Doi; H Yasue
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  154     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, 860-8556, Kumamoto City, Japan. kiyo@gpo.kumamoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / administration & dosage,  diagnostic use
Angina Pectoris, Variant / blood*,  diagnosis,  physiopathology
Biological Markers / blood
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Angiography
Coronary Vessels
Electrocardiography
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infusions, Intra-Arterial
Lipoproteins, LDL / blood*
Male
Middle Aged
Oxidation-Reduction*
Risk Factors
Severity of Illness Index
Vasodilation / drug effects
Vasodilator Agents / administration & dosage,  diagnostic use
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/Vasodilator Agents; 0/oxidized low density lipoprotein; 51-84-3/Acetylcholine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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