| Increase in the number of detectable preoptic glutamic acid decarboxylase 67-immunoreactive cells in immature male rats. | |
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MedLine Citation:
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PMID: 11377752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gonadotropin-releasing hormone (GnRH) neurons are mainly located in the anterior preoptic area (aPOA) and gamma-aminobutyric acid (GABA) is known as a potent regulator of the GnRH neurons. To examine the development of the GABAergic system in the aPOA, immunocytochemistry of glutamic acid decarboxylase 67 (GAD(67)) was performed in immature (postnatal d16, d25 and d30) and mature (postnatal 10 weeks) male rats. All immunocytochemical procedures were simultaneously performed. In the lateral part of the aPOA, the detectable number of GAD(67)-immunoreactive cells was small in the d16 group, but significantly increased in the d25, d30 and mature groups, up to 2.7, 4.8 and 5.7 times the number in the d16 group, respectively. In the diagonal band of Broca (DBB), the number was also small in the d16 group, and significantly increased in the d25, d30 and mature groups upto 1.8, 2.2 and 2.8 times the number in the d16 group, respectively. However, in the cingulate cortex, no significant developmental change was observed. These results suggest that the development of the GABAergic system in the lateral aPOA and the DBB occurs before sexual maturation of male rats. |
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Authors:
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D Mitsushima; D He; T Funabashi; K Shinohara; F Kimura |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience research Volume: 40 ISSN: 0168-0102 ISO Abbreviation: Neurosci. Res. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-08-16 Revised Date: 2007-10-24 |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 141-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan. dm650314@med.yokohama-cu.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Cell Count Cell Size / physiology Glutamate Decarboxylase / metabolism* Gonadotropin-Releasing Hormone / metabolism, secretion* Gyrus Cinguli / cytology, enzymology, growth & development Immunohistochemistry Isoenzymes / metabolism* Male Neurons / cytology, enzymology* Preoptic Area / cytology, enzymology*, growth & development* Rats Rats, Wistar Sex Differentiation / physiology Sexual Maturation / physiology* gamma-Aminobutyric Acid / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 33515-09-2/Gonadotropin-Releasing Hormone; 56-12-2/gamma-Aminobutyric Acid; EC 4.1.1.15/Glutamate Decarboxylase; EC 4.1.1.15/glutamate decarboxylase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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