| Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise. | |
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MedLine Citation:
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PMID: 15561388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Local metabolic changes are suggested to be involved in muscle pain development in humans. Nineteen women with chronic work-related trapezius myalgia (TM) and 20 healthy female controls (CON) were studied during baseline rest, 20 min repetitive low-force exercise, and 120 min recovery. Interstitial serotonin (5-HT), glutamate, lactate, pyruvate, and blood flow were determined by microdialysis in the trapezius muscle. Baseline pressure pain threshold (PPT) was lower (143+/-18 (TM) vs. 269+/-17 (CON)kPa) (mean+/-SEM), pain intensity (visual analogue scale, VAS) higher (33+/-5 vs. 2+/-1mm), muscle 5-HT higher (22.9+/-6.7 vs. 3.8+/-1.3 nmol/l), and glutamate higher (47+/-3 vs. 36+/-4 micromol/l) in TM than in CON (all P<0.05), whereas muscle blood flow was similar in groups. Furthermore, muscle pyruvate was higher (180+/-15 vs. 135+/-12 micromol/l) and lactate higher (4.4+/-0.3 vs. 3.1+/-0.3 mmol/l) in TM than in CON (P<0.001). In response to exercise, VAS and glutamate increased in both TM and CON (all P<0.05). In TM only, lactate and pyruvate increased significantly (P<0.02), whereas blood flow increased to similar levels in both groups. During the initial 20 min recovery period, blood flow remained increased in TM (P<0.005) whereas it decreased to baseline levels in CON. In conclusion, patients with chronic work-related TM have increased levels of muscle 5-HT and glutamate that were correlated to pain intensity (r=0.55, P<0.001) and PPT (r=-0.47, P<0.001), respectively. In addition, TM was associated with increased anaerobic metabolism, whereas a normal rise in blood flow was seen with exercise. These findings indicate that peripheral nociceptive processes are active in work-related TM. |
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Authors:
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Lars Rosendal; Britt Larsson; Jesper Kristiansen; Michael Peolsson; Karen Søgaard; Michael Kjaer; Jan Sørensen; Björn Gerdle |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pain Volume: 112 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-24 Completed Date: 2005-05-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
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Languages: eng Pagination: 324-34 Citation Subset: IM |
Affiliation:
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National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen, Denmark. LRL@ami.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Creatine
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blood Female Glutamic Acid / metabolism Humans L-Lactate Dehydrogenase / blood Lactic Acid / metabolism Microdialysis / methods Muscle, Skeletal / metabolism, pathology Occupational Diseases Pain / metabolism*, physiopathology Pain Measurement Physical Exertion / physiology* Pyruvic Acid / metabolism Regional Blood Flow / physiology Rest / physiology* Serotonin / metabolism Spectrophotometry Time Factors Ultrasonography / methods |
| Chemical | |
Reg. No./Substance:
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127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 50-67-9/Serotonin; 56-86-0/Glutamic Acid; 57-00-1/Creatine; EC 1.1.1.27/L-Lactate Dehydrogenase |
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