| Increase in leukotrienes in the coronary circulation by cooling: a study in the anesthetized dog. | |
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MedLine Citation:
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PMID: 10093297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pentobarbital-anesthetized dogs were instrumented for hemodynamic measurements and cooled by heat exchange tubes. Through a catheter in the coronary sinus, blood samples were obtained and plasma leukotrienes measured using a high-pressure liquid chromatography technique. Hemodynamic function was significantly reduced during cooling, and during subsequent rewarming hemodynamic function was only partly restored. Leukotriene C4 and B4 were significantly increased at a body core temperature of 31 degrees C and 25 degrees C during cooling but not during rewarming (28 degrees C) and after rewarming (37 degrees C). This indicates that during decreasing body temperature elevated leukotriene levels may increase vascular permeability, inflammation, and vasoactivity and counteract temperature-dependent decrease in these functions. Disturbed microcirculation may thus diminish cardiac recovery during rewarming. |
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Authors:
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K Ytrehus; T Tveita; O Hevroy |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of circumpolar health Volume: 57 Suppl 1 ISSN: 1239-9736 ISO Abbreviation: Int J Circumpolar Health Publication Date: 1998 |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9713056 Medline TA: Int J Circumpolar Health Country: FINLAND |
Other Details:
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Languages: eng Pagination: 316-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Tromsø, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Coronary Circulation / physiology* Disease Models, Animal Dogs Female Hemodynamics / physiology Hypothermia, Induced* Leukotrienes / biosynthesis*, blood Male Reference Values Rewarming Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Leukotrienes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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