| Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. | |
| | |
MedLine Citation:
|
PMID: 15448117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Interleukin (IL)-6, which is released from muscle tissue during intense exercise, possesses important metabolic and probably anti-inflammatory properties. To evaluate the IL-6 response to low-intensity exercise, we conducted two studies: 1) a control study with insertion of microdialysis catheters in muscle and determination of interstitial muscle IL-6 response over 2 h of rest and 2) an exercise study to investigate the IL-6 response to 20 min of repetitive low-force exercise. In both studies, a microdialysis catheter (cutoff: 3,000 kDa) was inserted into the upper trapezius muscle of six male subjects, and the catheters were perfused with Ringer-acetate at 5 microl/min. Venous plasma samples were taken in the exercise study. The insertion of microdialysis catheters into muscle resulted in an increase in IL-6 from 8 +/- 0 to 359 +/- 171 and 484 +/- 202 pg/ml after 65 and 110 min, respectively (P < 0.001). Similarly, in the exercise study, IL-6 increased to 289 +/- 128 pg/ml after a 55-min rest (P < 0.001). During the subsequent repetitive low-force exercise, muscle IL-6 further increased to 1,246 +/- 461 pg/ml and reached 2,132 +/- 477 pg/ml after a 30-min recovery (all P < 0.001). In contrast to this, plasma IL-6 did not significantly change in response to exercise. We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6. |
| | |
Authors:
|
Lars Rosendal; Karen Søgaard; Michael Kjaer; Gisela Sjøgaard; Henning Langberg; Jesper Kristiansen |
Related Documents
:
|
11601507 - Multisystem disorder associated with a missense mutation in the mitochondrial cytochrom... 19895607 - Contraction-induced changes in skeletal muscle na(+), k(+) pump mrna expression - impor... 10722807 - Immunosuppressive treatment affects cardiac and skeletal muscle mitochondria by the tox... 20216467 - Effects of preexercise feeding on markers of satellite cell activation. 22665007 - Urinary incontinence triggered by stretching exercises. 21660297 - Hypoxemia in patients with copd: cause, effects, and disease progression. |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2004-09-24 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 98 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-14 Completed Date: 2005-05-24 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 477-81 Citation Subset: IM |
Affiliation:
|
National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen, Denmark. LRL@ami.dk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Humans Interleukin-6 / blood*, physiology* Male Muscle Contraction / physiology* Muscle, Skeletal / physiology* Periodicity Physical Exertion / physiology* Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19...
Next Document: Left ventricular adaptations following short-term endurance training.