| Increase in the incidence of type 1 diabetes in Israeli children following the Second Lebanon War. | |
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MedLine Citation:
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PMID: 22151880 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Type 1 diabetes is an autoimmune disease occurring in genetically susceptible individuals. The precipitating cause is unclear. Recently, the Second Lebanon War exposed a large civilian population in northern Israel to significant psychological stress in the form of repeated barrages of missile attacks. HYPOTHESIS: We hypothesized that trends in regional incidence of type 1 diabetes before and after the war would reflect an association with stress. METHODS: All type 1 diabetes patients aged 0-17 yr who were reported to the Israel Juvenile Diabetes Register (n = 1822) in the four pre-war (2002-2005) and two post-war years (2006-2007) were included in the study. The patients were stratified by gender, age, ethnicity, family history of type 1 diabetes, season at diagnosis, and region of residency, namely, those who lived in the northern regions that were attacked and those in other regions. RESULTS: The post-war incidence of type 1 diabetes was increased in the northern regions (rate ratio, RR = 1.27; p = 0.037), with no change in the other regions. This change was more prominent in males (RR = 1.55; p = 0.005) but similar in summer and winter, in different ages, and in different ethnic groups. There was no change in the proportion of new patients with a family history of the disease. CONCLUSIONS: For the first time in a large population, we found a positive association between the trauma of war and an increase in the incidence of type 1 diabetes in children and adolescents. The increase in incidence was not associated with genetic susceptibility to the disease. |
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Authors:
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Amnon Zung; Orit Blumenfeld; Naim Shehadeh; Orna Dally Gottfried; Yardena Tenenbaum Rakover; Eli Hershkovitz; David Gillis; David Zangen; Orit Pinhas-Hamiel; Aaron Hanukoglu; Marianna Rachmiel; Shlomit Shalitin; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-13 |
Journal Detail:
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Title: Pediatric diabetes Volume: - ISSN: 1399-5448 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Pediatric Endocrinology Unit, Kaplan Medical Center, Hebrew University of Jerusalem, Rehovot, 76100, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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