Document Detail

Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude.
MedLine Citation:
PMID:  10834317     Owner:  NLM     Status:  MEDLINE    
The present study was performed to investigate the effects of exhaustive long lasting exercise at moderate altitude on the time course of serum immunomodulatory peptides, vascular endothelial growth factor (VEGF) and serum erythropoietin (EPO). Thirteen well trained runners participated at the Swiss Alpine Marathon of Davos (distance 67 km, altitude difference 2300 m). Interleukin-6 was significantly elevated in the first 2h after the run. In contrast, tumor necrosis factor-alpha and both soluble tumor necrosis factor-a receptors I and II were increased after exercise termination and showed sustained serum concentrations the following days. Neopterin, a serum marker for the activation of the cellular immune system, was increased until day two after the run. Immediately after the run VEGF was significantly elevated and further increased 2.4-fold until day five post exercise (p = 0.005). EPO was also increased after exercise but reached its maximum 2 h after the run (2-fold increase; p = 0.004) and decreased thereafter. The main findings of our study are that prolonged strenuous exercise at moderate altitude induced a significant long lasting increase in serum VEGF and EPO which was accompanied by an activation of the immune system.
W Schobersberger; P Hobisch-Hagen; D Fries; F Wiedermann; J Rieder-Scharinger; B Villiger; W Frey; M Herold; D Fuchs; W Jelkmann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunobiology     Volume:  201     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-08-09     Completed Date:  2000-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  611-20     Citation Subset:  IM; S    
Department for Anesthesia and Intensive Care Medicine, The Leopold-Franzens-University of Innsbruck, Austria.
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MeSH Terms
Blood Cell Count
Cytokines / blood
Endothelial Growth Factors / blood*
Erythropoietin / blood*
Exercise / physiology*
Immune System / physiology*
Interleukin-6 / blood
Lymphokines / blood*
Middle Aged
Neopterin / blood
Plasma Volume
Receptors, Tumor Necrosis Factor / blood
Running / physiology*
Time Factors
Tumor Necrosis Factor-alpha / analysis
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Reg. No./Substance:
0/Cytokines; 0/Endothelial Growth Factors; 0/Interleukin-6; 0/Lymphokines; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 11096-26-7/Erythropoietin; 670-65-5/Neopterin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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