| Increase in human endogenous retrovirus HERV-K (HML-2) viral load in active rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 19703019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the viral loads of human endogenous retrovirus HERV-K (HML-2) type 1 and type 2 in rheumatoid arthritis (RA), we measured the viral loads of HERV-K (HML-2) type 1 and type 2 using nucleic acid sequence-based amplification (NASBA) technology. We analyzed plasma samples from RA patients (n = 79) and healthy volunteers (HV, n = 46) and synovial fluid samples from RA (n = 10) and osteoarthritis (OA, n = 10) patients. HERV-K type 1 and type 2 viruses were detected and quantified for the majority of plasma and synovial fluid samples from RA patients. HERV-K type 1 and type 2 viral loads were significantly elevated in RA patients compared with HV in plasma (P < 0.0001) and from RA patients compared with OA patients in synovial fluid (type 1: P = 0.0007; type 2: P = 0.023). Moreover, an association was observed between the HERV-K type 1 viral load in plasma and the disease activity in RA patients (RA patients with low activity versus high activity P = 0.0129; RA patients with intermediate activity versus high activity P = 0.037). Our findings showed that HERV-K (HML-2) viral load can be detected in plasma samples from RA patients, with higher levels observed for those with active disease. There was an association of HERV-K type 1 levels with the disease activity. |
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Authors:
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F Reynier; T Verjat; F Turrel; P E Imbert; H Marotte; B Mougin; P Miossec |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 70 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 295-9 Citation Subset: IM |
Affiliation:
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Joint Unit Hospices Civils de Lyon - bioMérieux, and Department of Immunology and Rheumatology, Immunogenomics and inflammation research Unit EA 4130, University of Lyon, Lyon, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis, Rheumatoid / blood, virology* Endogenous Retroviruses / isolation & purification* Female Humans Male Middle Aged Osteoarthritis / blood, virology* Synovial Fluid / virology* Viral Load* |
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