| Increase in hepatic content of oleic acid induced by dehydroepiandrosterone in the rat. | |
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MedLine Citation:
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PMID: 10509745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of dehydroepiandrosterone (DHEA) on the acyl composition of lipids in rat liver were studied. The content of oleic acid (18:1) in hepatic lipids was increased markedly by feeding rats a diet containing 0.5% (w/w) DHEA for 14 days. Treatment of rats with DHEA caused an increase in the activity of the terminal desaturase of the stearoyl-CoA desaturation system, without changing either the activity of NADH-cytochrome b5 reductase or the microsomal content of cytochrome b5. Among the changes observed in hepatic lipids, the increase in 18:1 content in phosphatidylcholine (PtdCho) was the most prominent; an approximately 2.5-fold increase in the proportion of 18:1 was induced at position 2, but not at position 1, by DHEA. This selective elevation of 18:1 at position 2 of PtdCho seems to be produced by the concerted actions of the induced 1-acylglycerophosphocholine (1-acyl-GPC) acyltransferase and the induced stearoyl-CoA desaturase. The content of 18:1 in serum lipids was unchanged by DHEA treatment, suggesting that secretion of lipids containing 18:1 into the circulation was not affected by DHEA. These results suggest that the elevation of hepatic content of 18:1 caused by DHEA treatment is mainly due to the induction of stearoyl-CoA desaturase. |
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Authors:
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K Imai; M Koyama; N Kudo; A Shirahata; Y Kawashima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical pharmacology Volume: 58 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-08 Completed Date: 1999-10-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 925-33 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Saitama Cardiovascular and Respiratory Center, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dehydroepiandrosterone / pharmacology* Lipid Metabolism Liver / drug effects*, enzymology, metabolism Male Oleic Acid / blood, metabolism* Rats Rats, Wistar Stearoyl-CoA Desaturase / metabolism |
| Chemical | |
Reg. No./Substance:
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112-80-1/Oleic Acid; 53-43-0/Dehydroepiandrosterone; EC 1.14.19.1/Stearoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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