Document Detail

Increase in glucose consumption by acetylcysteine during hyperglycemic clamp. A study with healthy volunteers.
MedLine Citation:
PMID:  1530678     Owner:  NLM     Status:  MEDLINE    
Thiols have been shown to be related to insulin secretion and to uptake of glucose into tissues. In the present study the effects of i.v. administration of acetylcysteine (N-acetylcysteine, NAC, CAS 616-91-1) on glucose consumption and plasma free thiols were studied in young healthy volunteers during hyperglycemic clamp. NAC (0.5-2.0 mg/kg) significantly increased glucose consumption. This effect was not obvious at higher doses of NAC. Plasma free NAC depended on the dose of NAC injected. The t1/2 of NAC was 11 min. NAC produced significant increases of plasma cysteine concentrations, and a slight but insignificantly increase of plasma glutathione. These data suggest that a moderate increase in plasma thiols augments glucose consumption during hyperglycemic clamp.
H P Ammon; P H Müller; M Eggstein; C Wintermantel; B Aigner; H Safayhi; M Stützle; W Renn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  42     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  642-5     Citation Subset:  IM    
Department of Pharmacology, University of Tübingen, Fed. Rep. of Germany.
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MeSH Terms
Acetylcysteine / adverse effects,  pharmacokinetics,  pharmacology*
Blood Glucose / metabolism*
Glucose / metabolism*
Glutathione / blood
Insulin / blood
Models, Biological
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose; 616-91-1/Acetylcysteine; 70-18-8/Glutathione

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